Label-free DNA biosensing by topological light confinement

Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge the gap of large effective mode volume with large experimental quality factor. Relying on the transductio...

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Autores principales:	Zito Gianluigi, Sanità Gennaro, Guilcapi Alulema Bryan, Lara Yépez Sofía N., Lanzio Vittorino, Riminucci Fabrizio, Cabrini Stefano, Moccia Maria, Avitabile Concetta, Lamberti Annalisa, Mocella Vito, Rendina Ivo, Romano Silvia
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	biosensors bound states in the continuum dna photonic crystals Physics QC1-999
Acceso en línea:	https://doaj.org/article/a0d3ea8f98004004bfda01251c619e6f
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spelling	oai:doaj.org-article:a0d3ea8f98004004bfda01251c619e6f2021-12-05T14:10:56ZLabel-free DNA biosensing by topological light confinement2192-861410.1515/nanoph-2021-0396https://doaj.org/article/a0d3ea8f98004004bfda01251c619e6f2021-11-01T00:00:00Zhttps://doi.org/10.1515/nanoph-2021-0396https://doaj.org/toc/2192-8614Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge the gap of large effective mode volume with large experimental quality factor. Relying on the transduction mechanism of reactive sensing principle, herein, we first numerically study the potential of subwavelength confinement driven by topological decoupling from free space radiation for BIC-based biosensing. Then, we experimentally combine this capability with minimal and low-cost optical setup, applying the devised quasi-BIC resonator for PNA/DNA selective biosensing with real-time monitoring of the binding event. A sensitivity of 20 molecules per micron squared is achieved, i.e. ≃0.01 pg. Further enhancement can easily be envisaged, pointing out the possibility of single-molecule regime. This work aims at a precise and ultrasensitive approach for developing low-cost point-of-care tools suitable for routine disease prescreening analyses in laboratory, also adaptable to industrial production control.Zito GianluigiSanità GennaroGuilcapi Alulema BryanLara Yépez Sofía N.Lanzio VittorinoRiminucci FabrizioCabrini StefanoMoccia MariaAvitabile ConcettaLamberti AnnalisaMocella VitoRendina IvoRomano SilviaDe Gruyterarticlebiosensorsbound states in the continuumdnaphotonic crystalsPhysicsQC1-999ENNanophotonics, Vol 10, Iss 17, Pp 4279-4287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosensors bound states in the continuum dna photonic crystals Physics QC1-999
spellingShingle	biosensors bound states in the continuum dna photonic crystals Physics QC1-999 Zito Gianluigi Sanità Gennaro Guilcapi Alulema Bryan Lara Yépez Sofía N. Lanzio Vittorino Riminucci Fabrizio Cabrini Stefano Moccia Maria Avitabile Concetta Lamberti Annalisa Mocella Vito Rendina Ivo Romano Silvia Label-free DNA biosensing by topological light confinement
description	Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge the gap of large effective mode volume with large experimental quality factor. Relying on the transduction mechanism of reactive sensing principle, herein, we first numerically study the potential of subwavelength confinement driven by topological decoupling from free space radiation for BIC-based biosensing. Then, we experimentally combine this capability with minimal and low-cost optical setup, applying the devised quasi-BIC resonator for PNA/DNA selective biosensing with real-time monitoring of the binding event. A sensitivity of 20 molecules per micron squared is achieved, i.e. ≃0.01 pg. Further enhancement can easily be envisaged, pointing out the possibility of single-molecule regime. This work aims at a precise and ultrasensitive approach for developing low-cost point-of-care tools suitable for routine disease prescreening analyses in laboratory, also adaptable to industrial production control.
format	article
author	Zito Gianluigi Sanità Gennaro Guilcapi Alulema Bryan Lara Yépez Sofía N. Lanzio Vittorino Riminucci Fabrizio Cabrini Stefano Moccia Maria Avitabile Concetta Lamberti Annalisa Mocella Vito Rendina Ivo Romano Silvia
author_facet	Zito Gianluigi Sanità Gennaro Guilcapi Alulema Bryan Lara Yépez Sofía N. Lanzio Vittorino Riminucci Fabrizio Cabrini Stefano Moccia Maria Avitabile Concetta Lamberti Annalisa Mocella Vito Rendina Ivo Romano Silvia
author_sort	Zito Gianluigi
title	Label-free DNA biosensing by topological light confinement
title_short	Label-free DNA biosensing by topological light confinement
title_full	Label-free DNA biosensing by topological light confinement
title_fullStr	Label-free DNA biosensing by topological light confinement
title_full_unstemmed	Label-free DNA biosensing by topological light confinement
title_sort	label-free dna biosensing by topological light confinement
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a0d3ea8f98004004bfda01251c619e6f
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Label-free DNA biosensing by topological light confinement

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