Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex

Abstract In the interaural direction, translational linear acceleration is loaded during lateral translational movement and gravitational acceleration is loaded during lateral tilting movement. These two types of acceleration induce eye movements via two kinds of otolith-ocular reflexes to compensat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shotaro Harada, Takao Imai, Yasumitsu Takimoto, Yumi Ohta, Takashi Sato, Takefumi Kamakura, Noriaki Takeda, Tadashi Kitahara, Makoto Kondo, Yuya Ueno, Shoichi Shimada, Hidenori Inohara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0d401f000b54ab6a4a7c7be5decbbd8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0d401f000b54ab6a4a7c7be5decbbd8
record_format	dspace
spelling	oai:doaj.org-article:a0d401f000b54ab6a4a7c7be5decbbd82021-12-02T19:02:23ZDevelopment of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex10.1038/s41598-021-96596-x2045-2322https://doaj.org/article/a0d401f000b54ab6a4a7c7be5decbbd82021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96596-xhttps://doaj.org/toc/2045-2322Abstract In the interaural direction, translational linear acceleration is loaded during lateral translational movement and gravitational acceleration is loaded during lateral tilting movement. These two types of acceleration induce eye movements via two kinds of otolith-ocular reflexes to compensate for movement and maintain clear vision: horizontal eye movement during translational movement, and torsional eye movement (torsion) during tilting movement. Although the two types of acceleration cannot be discriminated, the two otolith-ocular reflexes can distinguish them effectively. In the current study, we tested whether lateral-eyed mice exhibit both of these otolith-ocular reflexes. In addition, we propose a new index for assessing the otolith-ocular reflex in mice. During lateral translational movement, mice did not show appropriate horizontal eye movement, but exhibited unnecessary vertical torsion-like eye movement that compensated for the angle between the body axis and gravito-inertial acceleration (GIA; i.e., the sum of gravity and inertial force due to movement) by interpreting GIA as gravity. Using the new index (amplitude of vertical component of eye movement)/(angle between body axis and GIA), the mouse otolith-ocular reflex can be assessed without determining whether the otolith-ocular reflex is induced during translational movement or during tilting movement.Shotaro HaradaTakao ImaiYasumitsu TakimotoYumi OhtaTakashi SatoTakefumi KamakuraNoriaki TakedaTadashi KitaharaMakoto KondoYuya UenoShoichi ShimadaHidenori InoharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shotaro Harada Takao Imai Yasumitsu Takimoto Yumi Ohta Takashi Sato Takefumi Kamakura Noriaki Takeda Tadashi Kitahara Makoto Kondo Yuya Ueno Shoichi Shimada Hidenori Inohara Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
description	Abstract In the interaural direction, translational linear acceleration is loaded during lateral translational movement and gravitational acceleration is loaded during lateral tilting movement. These two types of acceleration induce eye movements via two kinds of otolith-ocular reflexes to compensate for movement and maintain clear vision: horizontal eye movement during translational movement, and torsional eye movement (torsion) during tilting movement. Although the two types of acceleration cannot be discriminated, the two otolith-ocular reflexes can distinguish them effectively. In the current study, we tested whether lateral-eyed mice exhibit both of these otolith-ocular reflexes. In addition, we propose a new index for assessing the otolith-ocular reflex in mice. During lateral translational movement, mice did not show appropriate horizontal eye movement, but exhibited unnecessary vertical torsion-like eye movement that compensated for the angle between the body axis and gravito-inertial acceleration (GIA; i.e., the sum of gravity and inertial force due to movement) by interpreting GIA as gravity. Using the new index (amplitude of vertical component of eye movement)/(angle between body axis and GIA), the mouse otolith-ocular reflex can be assessed without determining whether the otolith-ocular reflex is induced during translational movement or during tilting movement.
format	article
author	Shotaro Harada Takao Imai Yasumitsu Takimoto Yumi Ohta Takashi Sato Takefumi Kamakura Noriaki Takeda Tadashi Kitahara Makoto Kondo Yuya Ueno Shoichi Shimada Hidenori Inohara
author_facet	Shotaro Harada Takao Imai Yasumitsu Takimoto Yumi Ohta Takashi Sato Takefumi Kamakura Noriaki Takeda Tadashi Kitahara Makoto Kondo Yuya Ueno Shoichi Shimada Hidenori Inohara
author_sort	Shotaro Harada
title	Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
title_short	Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
title_full	Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
title_fullStr	Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
title_full_unstemmed	Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
title_sort	development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0d401f000b54ab6a4a7c7be5decbbd8
work_keys_str_mv	AT shotaroharada developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT takaoimai developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT yasumitsutakimoto developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT yumiohta developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT takashisato developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT takefumikamakura developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT noriakitakeda developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT tadashikitahara developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT makotokondo developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT yuyaueno developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT shoichishimada developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex AT hidenoriinohara developmentofanewmethodforassessingotolithfunctioninmiceusingthreedimensionalbinocularanalysisoftheotolithocularreflex
_version_	1718377286009356288

Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex

Ejemplares similares