PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby impl...
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Nature Portfolio
2019
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oai:doaj.org-article:a0d6749bcea14e23bb0de1ac495322d32021-12-02T16:57:33ZPRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein10.1038/s41467-019-10127-x2041-1723https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10127-xhttps://doaj.org/toc/2041-1723Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.Min ThuraAbdul Qader Al-AidaroosAbhishek GuptaCheng Ean CheeSoo Chin LeeKam Man HuiJie LiYeoh Khay GuanWei Peng YongJimmy SoWee Joo ChngChin Hin NgJianbiao ZhouLing Zhi WangJohn Shyi Peng YuenHenry Sun Sien HoSim Mei YiEdmund ChiongSu Pin ChooJoanne NgeowMatthew Chau Hsien NgClarinda ChuaEugene Shen Ann YeoIain Bee Huat TanJoel Xuan En SngNicholas Yan Zhi TanJean Paul ThieryBoon Cher GohQi ZengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q Min Thura Abdul Qader Al-Aidaroos Abhishek Gupta Cheng Ean Chee Soo Chin Lee Kam Man Hui Jie Li Yeoh Khay Guan Wei Peng Yong Jimmy So Wee Joo Chng Chin Hin Ng Jianbiao Zhou Ling Zhi Wang John Shyi Peng Yuen Henry Sun Sien Ho Sim Mei Yi Edmund Chiong Su Pin Choo Joanne Ngeow Matthew Chau Hsien Ng Clarinda Chua Eugene Shen Ann Yeo Iain Bee Huat Tan Joel Xuan En Sng Nicholas Yan Zhi Tan Jean Paul Thiery Boon Cher Goh Qi Zeng PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
description |
Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen. |
format |
article |
author |
Min Thura Abdul Qader Al-Aidaroos Abhishek Gupta Cheng Ean Chee Soo Chin Lee Kam Man Hui Jie Li Yeoh Khay Guan Wei Peng Yong Jimmy So Wee Joo Chng Chin Hin Ng Jianbiao Zhou Ling Zhi Wang John Shyi Peng Yuen Henry Sun Sien Ho Sim Mei Yi Edmund Chiong Su Pin Choo Joanne Ngeow Matthew Chau Hsien Ng Clarinda Chua Eugene Shen Ann Yeo Iain Bee Huat Tan Joel Xuan En Sng Nicholas Yan Zhi Tan Jean Paul Thiery Boon Cher Goh Qi Zeng |
author_facet |
Min Thura Abdul Qader Al-Aidaroos Abhishek Gupta Cheng Ean Chee Soo Chin Lee Kam Man Hui Jie Li Yeoh Khay Guan Wei Peng Yong Jimmy So Wee Joo Chng Chin Hin Ng Jianbiao Zhou Ling Zhi Wang John Shyi Peng Yuen Henry Sun Sien Ho Sim Mei Yi Edmund Chiong Su Pin Choo Joanne Ngeow Matthew Chau Hsien Ng Clarinda Chua Eugene Shen Ann Yeo Iain Bee Huat Tan Joel Xuan En Sng Nicholas Yan Zhi Tan Jean Paul Thiery Boon Cher Goh Qi Zeng |
author_sort |
Min Thura |
title |
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
title_short |
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
title_full |
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
title_fullStr |
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
title_full_unstemmed |
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein |
title_sort |
prl3-zumab as an immunotherapy to inhibit tumors expressing prl3 oncoprotein |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d3 |
work_keys_str_mv |
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