PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby impl...

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Autores principales: Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d3
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spelling oai:doaj.org-article:a0d6749bcea14e23bb0de1ac495322d32021-12-02T16:57:33ZPRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein10.1038/s41467-019-10127-x2041-1723https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10127-xhttps://doaj.org/toc/2041-1723Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.Min ThuraAbdul Qader Al-AidaroosAbhishek GuptaCheng Ean CheeSoo Chin LeeKam Man HuiJie LiYeoh Khay GuanWei Peng YongJimmy SoWee Joo ChngChin Hin NgJianbiao ZhouLing Zhi WangJohn Shyi Peng YuenHenry Sun Sien HoSim Mei YiEdmund ChiongSu Pin ChooJoanne NgeowMatthew Chau Hsien NgClarinda ChuaEugene Shen Ann YeoIain Bee Huat TanJoel Xuan En SngNicholas Yan Zhi TanJean Paul ThieryBoon Cher GohQi ZengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
description Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.
format article
author Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
author_facet Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
author_sort Min Thura
title PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_short PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_full PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_fullStr PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_full_unstemmed PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_sort prl3-zumab as an immunotherapy to inhibit tumors expressing prl3 oncoprotein
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a0d6749bcea14e23bb0de1ac495322d3
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