YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.

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Auteurs principaux:	Hao Du, Ya Zhao, Jinqiu He, Yao Zhang, Hairui Xi, Mofang Liu, Jinbiao Ma, Ligang Wu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c
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spelling	oai:doaj.org-article:a0d827e86cce45c1a67683992d1edd1c2021-12-02T17:31:19ZYTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex10.1038/ncomms126262041-1723https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12626https://doaj.org/toc/2041-1723The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.Hao DuYa ZhaoJinqiu HeYao ZhangHairui XiMofang LiuJinbiao MaLigang WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Du Ya Zhao Jinqiu He Yao Zhang Hairui Xi Mofang Liu Jinbiao Ma Ligang Wu YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
description	The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.
format	article
author	Hao Du Ya Zhao Jinqiu He Yao Zhang Hairui Xi Mofang Liu Jinbiao Ma Ligang Wu
author_facet	Hao Du Ya Zhao Jinqiu He Yao Zhang Hairui Xi Mofang Liu Jinbiao Ma Ligang Wu
author_sort	Hao Du
title	YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_short	YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_full	YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_fullStr	YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_full_unstemmed	YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_sort	ythdf2 destabilizes m6a-containing rna through direct recruitment of the ccr4–not deadenylase complex
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c
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YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

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