YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.

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Autores principales: Hao Du, Ya Zhao, Jinqiu He, Yao Zhang, Hairui Xi, Mofang Liu, Jinbiao Ma, Ligang Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c
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spelling oai:doaj.org-article:a0d827e86cce45c1a67683992d1edd1c2021-12-02T17:31:19ZYTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex10.1038/ncomms126262041-1723https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12626https://doaj.org/toc/2041-1723The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.Hao DuYa ZhaoJinqiu HeYao ZhangHairui XiMofang LiuJinbiao MaLigang WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hao Du
Ya Zhao
Jinqiu He
Yao Zhang
Hairui Xi
Mofang Liu
Jinbiao Ma
Ligang Wu
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
description The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.
format article
author Hao Du
Ya Zhao
Jinqiu He
Yao Zhang
Hairui Xi
Mofang Liu
Jinbiao Ma
Ligang Wu
author_facet Hao Du
Ya Zhao
Jinqiu He
Yao Zhang
Hairui Xi
Mofang Liu
Jinbiao Ma
Ligang Wu
author_sort Hao Du
title YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_short YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_full YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_fullStr YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_full_unstemmed YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
title_sort ythdf2 destabilizes m6a-containing rna through direct recruitment of the ccr4–not deadenylase complex
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/a0d827e86cce45c1a67683992d1edd1c
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AT jinbiaoma ythdf2destabilizesm6acontainingrnathroughdirectrecruitmentoftheccr4notdeadenylasecomplex
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