Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in...

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Autores principales:	Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, Haroldo A. Toque, Zheng Dong, Xuejun Jiang, David J. Fulton, Neal L. Weintraub, Qinkai Li, Zsolt Bagi, Mei Hong, Detlev Boison, Chaodong Wu, Yuqing Huo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0da5f7197174e109b38d9b593754ec6
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spelling	oai:doaj.org-article:a0da5f7197174e109b38d9b593754ec62021-12-02T14:43:00ZRegulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation10.1038/s41467-017-00986-72041-1723https://doaj.org/article/a0da5f7197174e109b38d9b593754ec62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00986-7https://doaj.org/toc/2041-1723The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.Yiming XuYong WangSiyuan YanQiuhua YangYaqi ZhouXianqiu ZengZhiping LiuXiaofei AnHaroldo A. ToqueZheng DongXuejun JiangDavid J. FultonNeal L. WeintraubQinkai LiZsolt BagiMei HongDetlev BoisonChaodong WuYuqing HuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yiming Xu Yong Wang Siyuan Yan Qiuhua Yang Yaqi Zhou Xianqiu Zeng Zhiping Liu Xiaofei An Haroldo A. Toque Zheng Dong Xuejun Jiang David J. Fulton Neal L. Weintraub Qinkai Li Zsolt Bagi Mei Hong Detlev Boison Chaodong Wu Yuqing Huo Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
description	The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.
format	article
author	Yiming Xu Yong Wang Siyuan Yan Qiuhua Yang Yaqi Zhou Xianqiu Zeng Zhiping Liu Xiaofei An Haroldo A. Toque Zheng Dong Xuejun Jiang David J. Fulton Neal L. Weintraub Qinkai Li Zsolt Bagi Mei Hong Detlev Boison Chaodong Wu Yuqing Huo
author_facet	Yiming Xu Yong Wang Siyuan Yan Qiuhua Yang Yaqi Zhou Xianqiu Zeng Zhiping Liu Xiaofei An Haroldo A. Toque Zheng Dong Xuejun Jiang David J. Fulton Neal L. Weintraub Qinkai Li Zsolt Bagi Mei Hong Detlev Boison Chaodong Wu Yuqing Huo
author_sort	Yiming Xu
title	Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
title_short	Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
title_full	Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
title_fullStr	Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
title_full_unstemmed	Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
title_sort	regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0da5f7197174e109b38d9b593754ec6
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Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

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