Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila

Sleep is a fundamental behavior in an animal’s life influenced by many internal and external factors, such as aging and diet. Critically, poor sleep quality places people at risk of serious medical conditions. Because aging impairs quality of sleep, measures to improve sleep quality for elderly peop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sang Hyuk Lee, Eun Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	drosophila high-sucrose diet aging sleep fragmentation Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a0dbb5b5934a43a79076e6a60b61a989
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0dbb5b5934a43a79076e6a60b61a989
record_format	dspace
spelling	oai:doaj.org-article:a0dbb5b5934a43a79076e6a60b61a9892021-11-11T14:23:42ZShort-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila1976-83542151-248510.1080/19768354.2021.1997801https://doaj.org/article/a0dbb5b5934a43a79076e6a60b61a9892021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/19768354.2021.1997801https://doaj.org/toc/1976-8354https://doaj.org/toc/2151-2485Sleep is a fundamental behavior in an animal’s life influenced by many internal and external factors, such as aging and diet. Critically, poor sleep quality places people at risk of serious medical conditions. Because aging impairs quality of sleep, measures to improve sleep quality for elderly people are needed. Given that diet can influence many aspects of sleep, we investigated whether a high-sucrose diet (HSD) affected aging-induced sleep fragmentation using the fruit fly, Drosophila melanogaster. Drosophila is a valuable model for studying sleep due to its genetic tractability and many similarities with mammalian sleep. Total sleep duration, sleep bout numbers (SBN), and average sleep bout length (ABL) were compared between young and old flies on a normal sucrose diet (NSD) or HSD. On the NSD, old flies slept slightly more and showed increased SBN and reduced ABL, indicating increased sleep fragmentation. Short-term maintenance of flies in HSD (up to 8 days), but not long-term maintenance (up to 35 days), suppressed aging-induced sleep fragmentation. Our study provides meaningful strategies for preventing the deterioration of sleep quality in the elderly.Sang Hyuk LeeEun Young KimTaylor & Francis Grouparticledrosophilahigh-sucrose dietagingsleep fragmentationMedicine (General)R5-920Biology (General)QH301-705.5ENAnimal Cells and Systems, Vol 0, Iss 0, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drosophila high-sucrose diet aging sleep fragmentation Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	drosophila high-sucrose diet aging sleep fragmentation Medicine (General) R5-920 Biology (General) QH301-705.5 Sang Hyuk Lee Eun Young Kim Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
description	Sleep is a fundamental behavior in an animal’s life influenced by many internal and external factors, such as aging and diet. Critically, poor sleep quality places people at risk of serious medical conditions. Because aging impairs quality of sleep, measures to improve sleep quality for elderly people are needed. Given that diet can influence many aspects of sleep, we investigated whether a high-sucrose diet (HSD) affected aging-induced sleep fragmentation using the fruit fly, Drosophila melanogaster. Drosophila is a valuable model for studying sleep due to its genetic tractability and many similarities with mammalian sleep. Total sleep duration, sleep bout numbers (SBN), and average sleep bout length (ABL) were compared between young and old flies on a normal sucrose diet (NSD) or HSD. On the NSD, old flies slept slightly more and showed increased SBN and reduced ABL, indicating increased sleep fragmentation. Short-term maintenance of flies in HSD (up to 8 days), but not long-term maintenance (up to 35 days), suppressed aging-induced sleep fragmentation. Our study provides meaningful strategies for preventing the deterioration of sleep quality in the elderly.
format	article
author	Sang Hyuk Lee Eun Young Kim
author_facet	Sang Hyuk Lee Eun Young Kim
author_sort	Sang Hyuk Lee
title	Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
title_short	Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
title_full	Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
title_fullStr	Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
title_full_unstemmed	Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
title_sort	short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/a0dbb5b5934a43a79076e6a60b61a989
work_keys_str_mv	AT sanghyuklee shorttermmaintenanceonahighsucrosedietalleviatesaginginducedsleepfragmentationindrosophila AT eunyoungkim shorttermmaintenanceonahighsucrosedietalleviatesaginginducedsleepfragmentationindrosophila
_version_	1718438967406231552

Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation in drosophila

Ejemplares similares