PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.

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Autores principales:	Tao Chen, Jingjie Li, Meidong Xu, Qin Zhao, Yingyong Hou, Liqing Yao, Yunshi Zhong, Ping-Chieh Chou, Wei Zhang, Pinghong Zhou, Yuhui Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0e0e8babfbe49468e4dc2c1aad37390
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spelling	oai:doaj.org-article:a0e0e8babfbe49468e4dc2c1aad373902021-12-02T17:06:14ZPKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation10.1038/s41467-017-01024-22041-1723https://doaj.org/article/a0e0e8babfbe49468e4dc2c1aad373902017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01024-2https://doaj.org/toc/2041-1723In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.Tao ChenJingjie LiMeidong XuQin ZhaoYingyong HouLiqing YaoYunshi ZhongPing-Chieh ChouWei ZhangPinghong ZhouYuhui JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Chen Jingjie Li Meidong Xu Qin Zhao Yingyong Hou Liqing Yao Yunshi Zhong Ping-Chieh Chou Wei Zhang Pinghong Zhou Yuhui Jiang PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
description	In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.
format	article
author	Tao Chen Jingjie Li Meidong Xu Qin Zhao Yingyong Hou Liqing Yao Yunshi Zhong Ping-Chieh Chou Wei Zhang Pinghong Zhou Yuhui Jiang
author_facet	Tao Chen Jingjie Li Meidong Xu Qin Zhao Yingyong Hou Liqing Yao Yunshi Zhong Ping-Chieh Chou Wei Zhang Pinghong Zhou Yuhui Jiang
author_sort	Tao Chen
title	PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
title_short	PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
title_full	PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
title_fullStr	PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
title_full_unstemmed	PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
title_sort	pkcε phosphorylates miip and promotes colorectal cancer metastasis through inhibition of rela deacetylation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0e0e8babfbe49468e4dc2c1aad37390
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PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

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