PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.

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Detalles Bibliográficos
Autores principales: Tao Chen, Jingjie Li, Meidong Xu, Qin Zhao, Yingyong Hou, Liqing Yao, Yunshi Zhong, Ping-Chieh Chou, Wei Zhang, Pinghong Zhou, Yuhui Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/a0e0e8babfbe49468e4dc2c1aad37390
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