Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi

Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in...

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Autores principales:	Raimalynah Abd Razak, Meiny Suzery, Rafida Razali, Zarina Amin, Ruzaidi Azli Mohd Mokhtar, Ping Chin Lee, Cahyo Budiman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Plasmodium knowlesi Malaria Caseinolytic protease Plant extracts Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/a0e2b997ddd3433abc5b6b23f2aa7a81
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spelling	oai:doaj.org-article:a0e2b997ddd3433abc5b6b23f2aa7a812021-11-24T04:31:29ZTechnical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi2352-340910.1016/j.dib.2021.107588https://doaj.org/article/a0e2b997ddd3433abc5b6b23f2aa7a812021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352340921008635https://doaj.org/toc/2352-3409Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in the protein homeostasis molecular machinery and therefore be lethal for the parasite. While plants are considered excellent sources of bioactive compounds exhibiting inhibition activity towards Pk-ClpP, many local medicinal plants remain unexplored. This article expands the data collected from the inhibition properties of the methanolic extract of Asystasia gangetica (Chinese Violet), Alstonia scholaris (Pulai Tree), Piper retrofractum (Javanese Long Pepper) and Smallanthus sonchifolius (Yacon) towards Pk-ClpP. These plants are widely found in Malaysia and Indonesia and have been traditionally used in various medical treatments. The present dataset showed that the extracts contained phenolic and flavonoid compounds in various concentrations, whereby S. sonchifolius was found to have the lowest content of phenolic and flavonoid contents, while A. gangetica and A. scholaris were statistically comparable, yet higher than P. retrofactum and S. sonchifolus. Further inhibition data assay towards Pk-ClpP revealed that A. gangetica, A. scholaris and P. retrofactum demonstrated remarkable inhibition activity with IC50 values of 39.06 ± 1.98, 48.92 ± 1.52, and 87.63 ± 3.55, respectively. However, the inhibition activity of these extracts was significantly lower than a serine protease inhibitor of phenylmethylsulfonyl fluoridenone (PMSF). Meanwhile, S. sonchifolus did not exhibit significant inhibition activity towards Pk-ClpP. In addition, Pk-ClpP was not inhibited by a cysteine protease inhibitor of E64.Raimalynah Abd RazakMeiny SuzeryRafida RazaliZarina AminRuzaidi Azli Mohd MokhtarPing Chin LeeCahyo BudimanElsevierarticlePlasmodium knowlesiMalariaCaseinolytic proteasePlant extractsComputer applications to medicine. Medical informaticsR858-859.7Science (General)Q1-390ENData in Brief, Vol 39, Iss , Pp 107588- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plasmodium knowlesi Malaria Caseinolytic protease Plant extracts Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
spellingShingle	Plasmodium knowlesi Malaria Caseinolytic protease Plant extracts Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390 Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Ping Chin Lee Cahyo Budiman Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
description	Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in the protein homeostasis molecular machinery and therefore be lethal for the parasite. While plants are considered excellent sources of bioactive compounds exhibiting inhibition activity towards Pk-ClpP, many local medicinal plants remain unexplored. This article expands the data collected from the inhibition properties of the methanolic extract of Asystasia gangetica (Chinese Violet), Alstonia scholaris (Pulai Tree), Piper retrofractum (Javanese Long Pepper) and Smallanthus sonchifolius (Yacon) towards Pk-ClpP. These plants are widely found in Malaysia and Indonesia and have been traditionally used in various medical treatments. The present dataset showed that the extracts contained phenolic and flavonoid compounds in various concentrations, whereby S. sonchifolius was found to have the lowest content of phenolic and flavonoid contents, while A. gangetica and A. scholaris were statistically comparable, yet higher than P. retrofactum and S. sonchifolus. Further inhibition data assay towards Pk-ClpP revealed that A. gangetica, A. scholaris and P. retrofactum demonstrated remarkable inhibition activity with IC50 values of 39.06 ± 1.98, 48.92 ± 1.52, and 87.63 ± 3.55, respectively. However, the inhibition activity of these extracts was significantly lower than a serine protease inhibitor of phenylmethylsulfonyl fluoridenone (PMSF). Meanwhile, S. sonchifolus did not exhibit significant inhibition activity towards Pk-ClpP. In addition, Pk-ClpP was not inhibited by a cysteine protease inhibitor of E64.
format	article
author	Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Ping Chin Lee Cahyo Budiman
author_facet	Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Ping Chin Lee Cahyo Budiman
author_sort	Raimalynah Abd Razak
title	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_short	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_full	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_fullStr	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_full_unstemmed	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_sort	technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of plasmodium knowlesi
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a0e2b997ddd3433abc5b6b23f2aa7a81
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Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi

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