Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses

Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yeonkyung Park, Chiwon Ahn, Tae-Hyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0e2c4996d394d0d920752b180c4a523
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0e2c4996d394d0d920752b180c4a523
record_format	dspace
spelling	oai:doaj.org-article:a0e2c4996d394d0d920752b180c4a5232021-12-02T13:20:21ZOccupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses10.1038/s41598-021-81591-z2045-2322https://doaj.org/article/a0e2c4996d394d0d920752b180c4a5232021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81591-zhttps://doaj.org/toc/2045-2322Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and the Cochrane library from the earliest record to March, 2020. Case–control studies on occupational and environmental risk factors or on jobs with a risk of IPF were searched for. From 2490 relevant records, 12 studies were included. Any occupational or environmental exposure to metal dust (OR 1.83, 95% CI 1.15–2.91, I2 = 54%), wood dust (OR 1.62 5% CI 1.04–2.53, I2 = 5%) and pesticide (OR 2.07, 95% CI 1.24–3.45, I2 = 0%) were associated with an increased risk of IPF. Farming or agricultural work (OR 1.88, 95% CI 1.17–3.04, I2 = 67%) was also associated with an increased risk of IPF. Moreover, smoking increased IPF risk with an odds ratio of 1.39 (95% CI 1.01–1.91, I2 = 29%). In conclusion, metal dust, wood dust, pesticide, occupational history of farming or agriculture and ever smoking increased the risk of IPF.Yeonkyung ParkChiwon AhnTae-Hyung KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yeonkyung Park Chiwon Ahn Tae-Hyung Kim Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
description	Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and the Cochrane library from the earliest record to March, 2020. Case–control studies on occupational and environmental risk factors or on jobs with a risk of IPF were searched for. From 2490 relevant records, 12 studies were included. Any occupational or environmental exposure to metal dust (OR 1.83, 95% CI 1.15–2.91, I2 = 54%), wood dust (OR 1.62 5% CI 1.04–2.53, I2 = 5%) and pesticide (OR 2.07, 95% CI 1.24–3.45, I2 = 0%) were associated with an increased risk of IPF. Farming or agricultural work (OR 1.88, 95% CI 1.17–3.04, I2 = 67%) was also associated with an increased risk of IPF. Moreover, smoking increased IPF risk with an odds ratio of 1.39 (95% CI 1.01–1.91, I2 = 29%). In conclusion, metal dust, wood dust, pesticide, occupational history of farming or agriculture and ever smoking increased the risk of IPF.
format	article
author	Yeonkyung Park Chiwon Ahn Tae-Hyung Kim
author_facet	Yeonkyung Park Chiwon Ahn Tae-Hyung Kim
author_sort	Yeonkyung Park
title	Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
title_short	Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
title_full	Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
title_fullStr	Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
title_full_unstemmed	Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
title_sort	occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0e2c4996d394d0d920752b180c4a523
work_keys_str_mv	AT yeonkyungpark occupationalandenvironmentalriskfactorsofidiopathicpulmonaryfibrosisasystematicreviewandmetaanalyses AT chiwonahn occupationalandenvironmentalriskfactorsofidiopathicpulmonaryfibrosisasystematicreviewandmetaanalyses AT taehyungkim occupationalandenvironmentalriskfactorsofidiopathicpulmonaryfibrosisasystematicreviewandmetaanalyses
_version_	1718393229710196736

Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses

Ejemplares similares