Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects

Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the immunomodulatory effects of such treatment. Clinical...

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Autores principales:	Dihia Meghnem, Sharon A. Oldford, Ian D. Haidl, Lisa Barrett, Jean S. Marshall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0ea238050584e758838b44b7727969a
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spelling	oai:doaj.org-article:a0ea238050584e758838b44b7727969a2021-12-02T13:40:51ZHistamine receptor 2 blockade selectively impacts B and T cells in healthy subjects10.1038/s41598-021-88829-w2045-2322https://doaj.org/article/a0ea238050584e758838b44b7727969a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88829-whttps://doaj.org/toc/2045-2322Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the immunomodulatory effects of such treatment. Clinical reports have associated H2R blockade with leukopenia, neutropenia, and myelosuppression, and has been shown to provide clinical benefit in certain cancer settings. To systematically assess effects of H2R blockade on key immune parameters, a single-center, single-arm clinical study was conducted in 29 healthy subjects. Subjects received daily high dose ranitidine for 6 weeks. Peripheral blood immunophenotyping and mediator analysis were performed at baseline, 3 and 6 weeks into treatment, and 12 weeks after treatment cessation. Ranitidine was well-tolerated, and no drug related adverse events were observed. Ranitidine had no effect on number of neutrophils, basophils or eosinophils. However, ranitidine decreased numbers of B cells and IL-2Rα (CD25) expressing T cells that remained lower even after treatment cessation. Reduced serum levels of IL-2 were also observed and remained low after treatment. These observations highlight a previously unrecognised immunomodulatory sustained impact of H2R blockade. Therefore, the immune impacts of H2R blockade may require greater consideration in the context of vaccination and immunotherapy.Dihia MeghnemSharon A. OldfordIan D. HaidlLisa BarrettJean S. MarshallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dihia Meghnem Sharon A. Oldford Ian D. Haidl Lisa Barrett Jean S. Marshall Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
description	Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the immunomodulatory effects of such treatment. Clinical reports have associated H2R blockade with leukopenia, neutropenia, and myelosuppression, and has been shown to provide clinical benefit in certain cancer settings. To systematically assess effects of H2R blockade on key immune parameters, a single-center, single-arm clinical study was conducted in 29 healthy subjects. Subjects received daily high dose ranitidine for 6 weeks. Peripheral blood immunophenotyping and mediator analysis were performed at baseline, 3 and 6 weeks into treatment, and 12 weeks after treatment cessation. Ranitidine was well-tolerated, and no drug related adverse events were observed. Ranitidine had no effect on number of neutrophils, basophils or eosinophils. However, ranitidine decreased numbers of B cells and IL-2Rα (CD25) expressing T cells that remained lower even after treatment cessation. Reduced serum levels of IL-2 were also observed and remained low after treatment. These observations highlight a previously unrecognised immunomodulatory sustained impact of H2R blockade. Therefore, the immune impacts of H2R blockade may require greater consideration in the context of vaccination and immunotherapy.
format	article
author	Dihia Meghnem Sharon A. Oldford Ian D. Haidl Lisa Barrett Jean S. Marshall
author_facet	Dihia Meghnem Sharon A. Oldford Ian D. Haidl Lisa Barrett Jean S. Marshall
author_sort	Dihia Meghnem
title	Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
title_short	Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
title_full	Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
title_fullStr	Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
title_full_unstemmed	Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects
title_sort	histamine receptor 2 blockade selectively impacts b and t cells in healthy subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0ea238050584e758838b44b7727969a
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Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects

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