ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies

Park et al. characterise the interactome, localisation and function of Actin-Related Protein-Testis1 protein (ARP-T1), encoded by the ACTRT1 gene, associated with inherited basal cell cancer. They find that ARP-T1 is localised to the primary cilia basal body in epidermal cells, interacts with the ci...

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Autores principales:	Hyun-Sook Park, Eirini Papanastasi, Gabriela Blanchard, Elena Chiticariu, Daniel Bachmann, Markus Plomann, Fanny Morice-Picard, Pierre Vabres, Asma Smahi, Marcel Huber, Christine Pich, Daniel Hohl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a0f02e7c75a741a59d63e638f2446851
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spelling	oai:doaj.org-article:a0f02e7c75a741a59d63e638f24468512021-12-02T16:57:13ZARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies10.1038/s42003-021-02054-92399-3642https://doaj.org/article/a0f02e7c75a741a59d63e638f24468512021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02054-9https://doaj.org/toc/2399-3642Park et al. characterise the interactome, localisation and function of Actin-Related Protein-Testis1 protein (ARP-T1), encoded by the ACTRT1 gene, associated with inherited basal cell cancer. They find that ARP-T1 is localised to the primary cilia basal body in epidermal cells, interacts with the cilia machinery, and is needed for proper ciliogenesis.Hyun-Sook ParkEirini PapanastasiGabriela BlanchardElena ChiticariuDaniel BachmannMarkus PlomannFanny Morice-PicardPierre VabresAsma SmahiMarcel HuberChristine PichDaniel HohlNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun-Sook Park Eirini Papanastasi Gabriela Blanchard Elena Chiticariu Daniel Bachmann Markus Plomann Fanny Morice-Picard Pierre Vabres Asma Smahi Marcel Huber Christine Pich Daniel Hohl ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
description	Park et al. characterise the interactome, localisation and function of Actin-Related Protein-Testis1 protein (ARP-T1), encoded by the ACTRT1 gene, associated with inherited basal cell cancer. They find that ARP-T1 is localised to the primary cilia basal body in epidermal cells, interacts with the cilia machinery, and is needed for proper ciliogenesis.
format	article
author	Hyun-Sook Park Eirini Papanastasi Gabriela Blanchard Elena Chiticariu Daniel Bachmann Markus Plomann Fanny Morice-Picard Pierre Vabres Asma Smahi Marcel Huber Christine Pich Daniel Hohl
author_facet	Hyun-Sook Park Eirini Papanastasi Gabriela Blanchard Elena Chiticariu Daniel Bachmann Markus Plomann Fanny Morice-Picard Pierre Vabres Asma Smahi Marcel Huber Christine Pich Daniel Hohl
author_sort	Hyun-Sook Park
title	ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
title_short	ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
title_full	ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
title_fullStr	ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
title_full_unstemmed	ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
title_sort	arp-t1-associated bazex–dupré–christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0f02e7c75a741a59d63e638f2446851
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ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies

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