CD44 promotes hepatocellular carcinoma progression via upregulation of YAP

Abstract Hepatocellular carcinoma (HCC) is a common malignancy in human. CD44 is a transmembrane glycoprotein which is frequently overexpressed in cancer of various origins. The function and mechanism of CD44 in HCC remains elusive. In this study, we reported that CD44 was overexpressed in HCC to pr...

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Autores principales:	Jun Zhang, Xilin He, Yajie Wan, Honghong Zhang, Tao Tang, Meng Zhang, Shiyi Yu, Weiyong Zhao, Liming Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hepatocellular carcinoma CD44 YAP Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a0f2cfa14d3a42d0b8233f2d622ff2b1
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spelling	oai:doaj.org-article:a0f2cfa14d3a42d0b8233f2d622ff2b12021-11-21T12:07:59ZCD44 promotes hepatocellular carcinoma progression via upregulation of YAP10.1186/s40164-021-00247-w2162-3619https://doaj.org/article/a0f2cfa14d3a42d0b8233f2d622ff2b12021-11-01T00:00:00Zhttps://doi.org/10.1186/s40164-021-00247-whttps://doaj.org/toc/2162-3619Abstract Hepatocellular carcinoma (HCC) is a common malignancy in human. CD44 is a transmembrane glycoprotein which is frequently overexpressed in cancer of various origins. The function and mechanism of CD44 in HCC remains elusive. In this study, we reported that CD44 was overexpressed in HCC to promote the proliferation and migration of HCC cells via oncogenic YAP, which is the key downstream regulator in Hippo pathway. These findings suggest that CD44-YAP is a probable important axis in pathogenesis of HCC, providing an insight in to HCC pathogenesis as well as potential targets for the intervention of HCC.Jun ZhangXilin HeYajie WanHonghong ZhangTao TangMeng ZhangShiyi YuWeiyong ZhaoLiming ChenBMCarticleHepatocellular carcinomaCD44YAPDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENExperimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatocellular carcinoma CD44 YAP Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Hepatocellular carcinoma CD44 YAP Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jun Zhang Xilin He Yajie Wan Honghong Zhang Tao Tang Meng Zhang Shiyi Yu Weiyong Zhao Liming Chen CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
description	Abstract Hepatocellular carcinoma (HCC) is a common malignancy in human. CD44 is a transmembrane glycoprotein which is frequently overexpressed in cancer of various origins. The function and mechanism of CD44 in HCC remains elusive. In this study, we reported that CD44 was overexpressed in HCC to promote the proliferation and migration of HCC cells via oncogenic YAP, which is the key downstream regulator in Hippo pathway. These findings suggest that CD44-YAP is a probable important axis in pathogenesis of HCC, providing an insight in to HCC pathogenesis as well as potential targets for the intervention of HCC.
format	article
author	Jun Zhang Xilin He Yajie Wan Honghong Zhang Tao Tang Meng Zhang Shiyi Yu Weiyong Zhao Liming Chen
author_facet	Jun Zhang Xilin He Yajie Wan Honghong Zhang Tao Tang Meng Zhang Shiyi Yu Weiyong Zhao Liming Chen
author_sort	Jun Zhang
title	CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
title_short	CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
title_full	CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
title_fullStr	CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
title_full_unstemmed	CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
title_sort	cd44 promotes hepatocellular carcinoma progression via upregulation of yap
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a0f2cfa14d3a42d0b8233f2d622ff2b1
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CD44 promotes hepatocellular carcinoma progression via upregulation of YAP

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