Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

Abstract To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawl...

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Autores principales:	Dong Liang, Jing Ma, Bo Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0f98b5978a74b73b1d71af73e90edb4
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spelling	oai:doaj.org-article:a0f98b5978a74b73b1d71af73e90edb42021-12-02T13:57:37ZOral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness10.1038/s41598-021-82044-32045-2322https://doaj.org/article/a0f98b5978a74b73b1d71af73e90edb42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82044-3https://doaj.org/toc/2045-2322Abstract To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats.Dong LiangJing MaBo WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Liang Jing Ma Bo Wei Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
description	Abstract To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly decreased the extent of moxifloxacin oral absorption. The coadministration of moxifloxacin with Maalox to either control or TS rats caused significant reductions in the rate and extent of moxifloxacin absorption. In contrast, the coadministration of moxifloxacin with Pepto-Bismol to TS rats had no significant effect on either the rate or the extent of moxifloxacin absorption. These interactions showed dose staggering when oral administrations of Pepto-Bismol and moxifloxacin were separated by 60 min in control rats but not in TS rats. Dose staggering was more apparent after the coadministration of Maalox and moxifloxacin in TS rats.
format	article
author	Dong Liang Jing Ma Bo Wei
author_facet	Dong Liang Jing Ma Bo Wei
author_sort	Dong Liang
title	Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_short	Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_full	Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_fullStr	Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_full_unstemmed	Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
title_sort	oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0f98b5978a74b73b1d71af73e90edb4
work_keys_str_mv	AT dongliang oralabsorptionanddruginteractionkineticsofmoxifloxacininananimalmodelofweightlessness AT jingma oralabsorptionanddruginteractionkineticsofmoxifloxacininananimalmodelofweightlessness AT bowei oralabsorptionanddruginteractionkineticsofmoxifloxacininananimalmodelofweightlessness
_version_	1718392277364113408

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

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