Disposition and Residue Depletion of Metronidazole in Pigs and Broilers

Abstract Metronidazole (MNZ) is used in veterinary medicine for the treatment of anaerobic infections and a variety of protozoal and parasitic diseases. Current study has been conducted to examine the disposition and residue depletion studies of MNZ and its main metabolites in pigs and broilers. Aft...

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Autores principales:	Yuanhu Pan, Jiliang Yi, Bo Zhou, Shuyu Xie, Dongmei Chen, Yanfei Tao, Wei Qu, Zhenli Liu, Lingli Huang, Zonghui Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0fd5bef95b34193b275781b0cc0c250
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spelling	oai:doaj.org-article:a0fd5bef95b34193b275781b0cc0c2502021-12-02T15:06:23ZDisposition and Residue Depletion of Metronidazole in Pigs and Broilers10.1038/s41598-017-07443-x2045-2322https://doaj.org/article/a0fd5bef95b34193b275781b0cc0c2502017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07443-xhttps://doaj.org/toc/2045-2322Abstract Metronidazole (MNZ) is used in veterinary medicine for the treatment of anaerobic infections and a variety of protozoal and parasitic diseases. Current study has been conducted to examine the disposition and residue depletion studies of MNZ and its main metabolites in pigs and broilers. After a single oral administration of MNZ, the concentrations of MNZ and its main metabolites in the excreta of pigs and broilers were determined by LC-MS/MS. More than 75% of the drug was recovered within 14 days, of which MNZ accounted for about 40%, MNZ-OH 20–25% and MAA less than 10%. The residue depletion study showed that MNZ was the most predominant residue in all of the tissues and could be detected in liver, kidney and muscle up to the withdrawal time of 14 days. MNZ-OH concentrations were lower than MNZ in all of the tissues, but its elimination half-life was close to MNZ. It is proposed that kidney and muscle are appropriate residue target tissues and both MNZ and its hydroxylated metabolite, MNZ-OH, should be monitored in the routine surveillance of MNZ related residues in food of animal origin.Yuanhu PanJiliang YiBo ZhouShuyu XieDongmei ChenYanfei TaoWei QuZhenli LiuLingli HuangZonghui YuanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuanhu Pan Jiliang Yi Bo Zhou Shuyu Xie Dongmei Chen Yanfei Tao Wei Qu Zhenli Liu Lingli Huang Zonghui Yuan Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
description	Abstract Metronidazole (MNZ) is used in veterinary medicine for the treatment of anaerobic infections and a variety of protozoal and parasitic diseases. Current study has been conducted to examine the disposition and residue depletion studies of MNZ and its main metabolites in pigs and broilers. After a single oral administration of MNZ, the concentrations of MNZ and its main metabolites in the excreta of pigs and broilers were determined by LC-MS/MS. More than 75% of the drug was recovered within 14 days, of which MNZ accounted for about 40%, MNZ-OH 20–25% and MAA less than 10%. The residue depletion study showed that MNZ was the most predominant residue in all of the tissues and could be detected in liver, kidney and muscle up to the withdrawal time of 14 days. MNZ-OH concentrations were lower than MNZ in all of the tissues, but its elimination half-life was close to MNZ. It is proposed that kidney and muscle are appropriate residue target tissues and both MNZ and its hydroxylated metabolite, MNZ-OH, should be monitored in the routine surveillance of MNZ related residues in food of animal origin.
format	article
author	Yuanhu Pan Jiliang Yi Bo Zhou Shuyu Xie Dongmei Chen Yanfei Tao Wei Qu Zhenli Liu Lingli Huang Zonghui Yuan
author_facet	Yuanhu Pan Jiliang Yi Bo Zhou Shuyu Xie Dongmei Chen Yanfei Tao Wei Qu Zhenli Liu Lingli Huang Zonghui Yuan
author_sort	Yuanhu Pan
title	Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
title_short	Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
title_full	Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
title_fullStr	Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
title_full_unstemmed	Disposition and Residue Depletion of Metronidazole in Pigs and Broilers
title_sort	disposition and residue depletion of metronidazole in pigs and broilers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0fd5bef95b34193b275781b0cc0c250
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Disposition and Residue Depletion of Metronidazole in Pigs and Broilers

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