Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents

Erik Pierstorff1, Dean Ho1,21Departments of Biomedical and Mechanical Engineering, Robert R McCormick School of Engineering and Applied Science; 2Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, IL, USAAbstract: The release of therapeutic dr...

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Autores principales:	Erik Pierstorff, Dean Ho
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a0ff448fe21d44b9bba463f7eed89dd7
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spelling	oai:doaj.org-article:a0ff448fe21d44b9bba463f7eed89dd72021-12-02T05:02:09ZNanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents1176-91141178-2013https://doaj.org/article/a0ff448fe21d44b9bba463f7eed89dd72008-12-01T00:00:00Zhttp://www.dovepress.com/nanomembrane-driven-co-elution-and-integration-of-active-chemotherapeu-a2697https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Erik Pierstorff1, Dean Ho1,21Departments of Biomedical and Mechanical Engineering, Robert R McCormick School of Engineering and Applied Science; 2Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, IL, USAAbstract: The release of therapeutic drugs from the surface of implantable devices is instrumental for the reduction of medical costs and toxicity associated with systemic administration. In this study we demonstrate the triblock copolymer-mediated deposition and release of multiple therapeutics from a single thin film at the air-water interface via Langmuir&ndash;Blodgett deposition. The dual drug elution of dexamethasone (Dex) and doxorubicin hydrochloride (Dox) from the thin film is measured by response in the RAW 264.7 murine&nbsp;macrophage cell line. The integrated hydrophilic and hydrophobic components of the polymer structure allows for the creation of hybrids of the copolymer and the hydrophobic Dex and the hydrophilic Dox. Confirmation of drug release and functionality was demonstrated via suppression of the interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF&alpha;) inflammatory cytokines (Dex), as well as TUNEL staining and DNA fragmentation analysis (Dox). The inherent biocompatibility of the copolymeric material is further demonstrated by the lack of inflammation and apoptosis induction in cells grown on the copolymer films. Thus a layer-by-layer anchored deposition of an anti-inflammatory and chemotherapeutic functionalized copolymer film is able to localize drug dosage to the surface of a medical device, all with an innate material thickness of 4 nm per layer.Keywords: co-elution, combinatorial therapy, nanomedicine, drug delivery, chemotherapy, inflammation Erik PierstorffDean HoDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 425-433 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Erik Pierstorff Dean Ho Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
description	Erik Pierstorff1, Dean Ho1,21Departments of Biomedical and Mechanical Engineering, Robert R McCormick School of Engineering and Applied Science; 2Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, IL, USAAbstract: The release of therapeutic drugs from the surface of implantable devices is instrumental for the reduction of medical costs and toxicity associated with systemic administration. In this study we demonstrate the triblock copolymer-mediated deposition and release of multiple therapeutics from a single thin film at the air-water interface via Langmuir&ndash;Blodgett deposition. The dual drug elution of dexamethasone (Dex) and doxorubicin hydrochloride (Dox) from the thin film is measured by response in the RAW 264.7 murine&nbsp;macrophage cell line. The integrated hydrophilic and hydrophobic components of the polymer structure allows for the creation of hybrids of the copolymer and the hydrophobic Dex and the hydrophilic Dox. Confirmation of drug release and functionality was demonstrated via suppression of the interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF&alpha;) inflammatory cytokines (Dex), as well as TUNEL staining and DNA fragmentation analysis (Dox). The inherent biocompatibility of the copolymeric material is further demonstrated by the lack of inflammation and apoptosis induction in cells grown on the copolymer films. Thus a layer-by-layer anchored deposition of an anti-inflammatory and chemotherapeutic functionalized copolymer film is able to localize drug dosage to the surface of a medical device, all with an innate material thickness of 4 nm per layer.Keywords: co-elution, combinatorial therapy, nanomedicine, drug delivery, chemotherapy, inflammation
format	article
author	Erik Pierstorff Dean Ho
author_facet	Erik Pierstorff Dean Ho
author_sort	Erik Pierstorff
title	Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
title_short	Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
title_full	Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
title_fullStr	Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
title_full_unstemmed	Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
title_sort	nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a0ff448fe21d44b9bba463f7eed89dd7
work_keys_str_mv	AT erikpierstorff nanomembranedrivencoelutionandintegrationofactivechemotherapeuticandantiinflammatoryagents AT deanho nanomembranedrivencoelutionandintegrationofactivechemotherapeuticandantiinflammatoryagents
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Nanomembrane-driven co-elution and integration of active chemotherapeutic and anti-inflammatory agents

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