Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study
Abstract It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome amon...
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Nature Portfolio
2021
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oai:doaj.org-article:a0ff995870f94b2fb85349c642186bb52021-12-02T16:50:25ZAssociation of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study10.1038/s41598-021-94467-z2045-2322https://doaj.org/article/a0ff995870f94b2fb85349c642186bb52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94467-zhttps://doaj.org/toc/2045-2322Abstract It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as ≥ 40% reduction in estimated glomerular filtration rate to < 60 mL/min/1.73 m2, or a diagnosis of end stage renal disease. Regarding baseline BP, the group of systolic BP (SBP) 120–129 mmHg had the lowest risk of the renal outcome, which increased more than 60% in SBP ≥ 130 mmHg group. A significant increase in the renal outcome was found only in the group of diastolic BP ≥ 90 mmHg. The group of BP < 130/80 mmHg had a benefit for lowering the risk regardless of the presence of proteinuria, and it significantly reduced the risk in patients with proteinuria. Achieving SBP level < 130 mmHg after one year resulted in a 42% risk reduction in patients with SBP level ≥ 130 mmHg at baseline. Targeting SBP level < 130 mmHg would be associated with the preferable renal outcome. Clinical Trial Registration-URL: https://www.umin.ac.jp/ctr/ . Unique identifier: UMIN000001159 (16/05/2008).Mariko Tsuchida-NishiwakiHaruhito A. UchidaHidemi TakeuchiNoriyuki NishiwakiYohei MaeshimaChie SaitoHitoshi SugiyamaJun WadaIchiei NaritaTsuyoshi WatanabeSeiichi MatsuoHirofumi MakinoAkira HishidaKunihiro YamagataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Mariko Tsuchida-Nishiwaki Haruhito A. Uchida Hidemi Takeuchi Noriyuki Nishiwaki Yohei Maeshima Chie Saito Hitoshi Sugiyama Jun Wada Ichiei Narita Tsuyoshi Watanabe Seiichi Matsuo Hirofumi Makino Akira Hishida Kunihiro Yamagata Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| description |
Abstract It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as ≥ 40% reduction in estimated glomerular filtration rate to < 60 mL/min/1.73 m2, or a diagnosis of end stage renal disease. Regarding baseline BP, the group of systolic BP (SBP) 120–129 mmHg had the lowest risk of the renal outcome, which increased more than 60% in SBP ≥ 130 mmHg group. A significant increase in the renal outcome was found only in the group of diastolic BP ≥ 90 mmHg. The group of BP < 130/80 mmHg had a benefit for lowering the risk regardless of the presence of proteinuria, and it significantly reduced the risk in patients with proteinuria. Achieving SBP level < 130 mmHg after one year resulted in a 42% risk reduction in patients with SBP level ≥ 130 mmHg at baseline. Targeting SBP level < 130 mmHg would be associated with the preferable renal outcome. Clinical Trial Registration-URL: https://www.umin.ac.jp/ctr/ . Unique identifier: UMIN000001159 (16/05/2008). |
| format |
article |
| author |
Mariko Tsuchida-Nishiwaki Haruhito A. Uchida Hidemi Takeuchi Noriyuki Nishiwaki Yohei Maeshima Chie Saito Hitoshi Sugiyama Jun Wada Ichiei Narita Tsuyoshi Watanabe Seiichi Matsuo Hirofumi Makino Akira Hishida Kunihiro Yamagata |
| author_facet |
Mariko Tsuchida-Nishiwaki Haruhito A. Uchida Hidemi Takeuchi Noriyuki Nishiwaki Yohei Maeshima Chie Saito Hitoshi Sugiyama Jun Wada Ichiei Narita Tsuyoshi Watanabe Seiichi Matsuo Hirofumi Makino Akira Hishida Kunihiro Yamagata |
| author_sort |
Mariko Tsuchida-Nishiwaki |
| title |
Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| title_short |
Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| title_full |
Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| title_fullStr |
Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| title_full_unstemmed |
Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study |
| title_sort |
association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of from-j study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a0ff995870f94b2fb85349c642186bb5 |
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