Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation

Endocannabinoid levels are controlled by the fine balance between their synthesis and degradation. Here, the authors show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum via a lasting increase in GABA release.

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Autores principales:	Christophe J. Dubois, Jessica Fawcett-Patel, Paul A. Katzman, Siqiong June Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1013e84bc8f456f9b6ed4ed0194fa05
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spelling	oai:doaj.org-article:a1013e84bc8f456f9b6ed4ed0194fa052021-12-02T13:57:22ZInhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation10.1038/s41467-020-20121-32041-1723https://doaj.org/article/a1013e84bc8f456f9b6ed4ed0194fa052020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20121-3https://doaj.org/toc/2041-1723Endocannabinoid levels are controlled by the fine balance between their synthesis and degradation. Here, the authors show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum via a lasting increase in GABA release.Christophe J. DuboisJessica Fawcett-PatelPaul A. KatzmanSiqiong June LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christophe J. Dubois Jessica Fawcett-Patel Paul A. Katzman Siqiong June Liu Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
description	Endocannabinoid levels are controlled by the fine balance between their synthesis and degradation. Here, the authors show that memory formation through fear conditioning selectively accelerates the degradation of endocannabinoids in the cerebellum via a lasting increase in GABA release.
format	article
author	Christophe J. Dubois Jessica Fawcett-Patel Paul A. Katzman Siqiong June Liu
author_facet	Christophe J. Dubois Jessica Fawcett-Patel Paul A. Katzman Siqiong June Liu
author_sort	Christophe J. Dubois
title	Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
title_short	Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
title_full	Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
title_fullStr	Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
title_full_unstemmed	Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
title_sort	inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a1013e84bc8f456f9b6ed4ed0194fa05
work_keys_str_mv	AT christophejdubois inhibitoryneurotransmissiondrivesendocannabinoiddegradationtopromotememoryconsolidation AT jessicafawcettpatel inhibitoryneurotransmissiondrivesendocannabinoiddegradationtopromotememoryconsolidation AT paulakatzman inhibitoryneurotransmissiondrivesendocannabinoiddegradationtopromotememoryconsolidation AT siqiongjuneliu inhibitoryneurotransmissiondrivesendocannabinoiddegradationtopromotememoryconsolidation
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Inhibitory neurotransmission drives endocannabinoid degradation to promote memory consolidation

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