Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe

Abstract The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. O...

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Autores principales:	Jack M. Crook, Ivana Murphy, Daniel P. Carter, Steven T. Pullan, Miles Carroll, Richard Vipond, Andrew A. Cunningham, Diana Bell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1019b0ed0ad43a695e4866f7a28a6e9
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spelling	oai:doaj.org-article:a1019b0ed0ad43a695e4866f7a28a6e92021-12-02T17:57:15ZMetagenomic identification of a new sarbecovirus from horseshoe bats in Europe10.1038/s41598-021-94011-z2045-2322https://doaj.org/article/a1019b0ed0ad43a695e4866f7a28a6e92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94011-zhttps://doaj.org/toc/2045-2322Abstract The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. Our results extend both the geographic and species ranges of sarbecoviruses and suggest their presence throughout the horseshoe bat distribution. Within the spike protein receptor binding domain, but excluding the receptor binding motif, RhGB01 has a 77% (SARS-CoV-2) and 81% (SARS-CoV) amino acid homology. While apparently lacking hACE2 binding ability, and hence unlikely to be zoonotic without mutation, RhGB01 presents opportunity for SARS-CoV-2 and other sarbecovirus homologous recombination. Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection are underestimated. Preventing transmission of SARS-CoV-2 to bats is critical with the current global mass vaccination campaign against this virus.Jack M. CrookIvana MurphyDaniel P. CarterSteven T. PullanMiles CarrollRichard VipondAndrew A. CunninghamDiana BellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jack M. Crook Ivana Murphy Daniel P. Carter Steven T. Pullan Miles Carroll Richard Vipond Andrew A. Cunningham Diana Bell Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
description	Abstract The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. Our results extend both the geographic and species ranges of sarbecoviruses and suggest their presence throughout the horseshoe bat distribution. Within the spike protein receptor binding domain, but excluding the receptor binding motif, RhGB01 has a 77% (SARS-CoV-2) and 81% (SARS-CoV) amino acid homology. While apparently lacking hACE2 binding ability, and hence unlikely to be zoonotic without mutation, RhGB01 presents opportunity for SARS-CoV-2 and other sarbecovirus homologous recombination. Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection are underestimated. Preventing transmission of SARS-CoV-2 to bats is critical with the current global mass vaccination campaign against this virus.
format	article
author	Jack M. Crook Ivana Murphy Daniel P. Carter Steven T. Pullan Miles Carroll Richard Vipond Andrew A. Cunningham Diana Bell
author_facet	Jack M. Crook Ivana Murphy Daniel P. Carter Steven T. Pullan Miles Carroll Richard Vipond Andrew A. Cunningham Diana Bell
author_sort	Jack M. Crook
title	Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
title_short	Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
title_full	Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
title_fullStr	Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
title_full_unstemmed	Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe
title_sort	metagenomic identification of a new sarbecovirus from horseshoe bats in europe
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1019b0ed0ad43a695e4866f7a28a6e9
work_keys_str_mv	AT jackmcrook metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT ivanamurphy metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT danielpcarter metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT steventpullan metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT milescarroll metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT richardvipond metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT andrewacunningham metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope AT dianabell metagenomicidentificationofanewsarbecovirusfromhorseshoebatsineurope
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Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe

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