Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer

Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Cur...

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Autores principales:	Matthew D. Laramie, Benjamin L. Fouts, William M. MacCuaig, Emmanuel Buabeng, Meredith A. Jones, Priyabrata Mukherjee, Bahareh Behkam, Lacey R. McNally, Maged Henary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1050fb86c204867a017ee7d6fe47964
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spelling	oai:doaj.org-article:a1050fb86c204867a017ee7d6fe479642021-12-02T16:23:14ZImproved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer10.1038/s41598-021-83658-32045-2322https://doaj.org/article/a1050fb86c204867a017ee7d6fe479642021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83658-3https://doaj.org/toc/2045-2322Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.Matthew D. LaramieBenjamin L. FoutsWilliam M. MacCuaigEmmanuel BuabengMeredith A. JonesPriyabrata MukherjeeBahareh BehkamLacey R. McNallyMaged HenaryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
description	Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.
format	article
author	Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary
author_facet	Matthew D. Laramie Benjamin L. Fouts William M. MacCuaig Emmanuel Buabeng Meredith A. Jones Priyabrata Mukherjee Bahareh Behkam Lacey R. McNally Maged Henary
author_sort	Matthew D. Laramie
title	Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
title_short	Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
title_full	Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
title_fullStr	Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
title_full_unstemmed	Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
title_sort	improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1050fb86c204867a017ee7d6fe47964
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Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer

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