Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice

Zearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the...

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Autores principales:	Xin Wang, Hao Yu, Anshan Shan, Yongcheng Jin, Hengtong Fang, Yun Zhao, Jinglin Shen, Changhai Zhou, Yongfeng Zhou, Yurong Fu, Junmei Wang, Jing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	zearalenone toxic effects intestinal microflora mucosal immunity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a10531341ecf459c8399486943fca879
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spelling	oai:doaj.org-article:a10531341ecf459c8399486943fca8792021-11-26T11:19:46ZToxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice0954-01051465-344310.1080/09540105.2018.1503233https://doaj.org/article/a10531341ecf459c8399486943fca8792018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1503233https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Zearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the effects of short-term ZEA exposure on mucosal immunity and the microecological balance of the intestine. We found that the morphological structure of the intestinal mucosa in mice was severely destroyed after ZEA was administered by gavage for one week, and the mRNA expression levels of mucosal β-defensin, Mucin-1, Mucin-2, interleukin-1beta (IL-1β), and tumour necrosis factor-α (TNF-α) and secretory immunoglobulin A (sIgA) levels were significantly increased. In addition, the intestinal microflora was altered by ZEA. Our study showed that ZEA not only caused inflammation of the mucous membrane but also disturbed the microecological balance of the intestine in mice.Xin WangHao YuAnshan ShanYongcheng JinHengtong FangYun ZhaoJinglin ShenChanghai ZhouYongfeng ZhouYurong FuJunmei WangJing ZhangTaylor & Francis Grouparticlezearalenonetoxic effectsintestinal microfloramucosal immunityAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 1002-1011 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	zearalenone toxic effects intestinal microflora mucosal immunity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	zearalenone toxic effects intestinal microflora mucosal immunity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Xin Wang Hao Yu Anshan Shan Yongcheng Jin Hengtong Fang Yun Zhao Jinglin Shen Changhai Zhou Yongfeng Zhou Yurong Fu Junmei Wang Jing Zhang Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
description	Zearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the effects of short-term ZEA exposure on mucosal immunity and the microecological balance of the intestine. We found that the morphological structure of the intestinal mucosa in mice was severely destroyed after ZEA was administered by gavage for one week, and the mRNA expression levels of mucosal β-defensin, Mucin-1, Mucin-2, interleukin-1beta (IL-1β), and tumour necrosis factor-α (TNF-α) and secretory immunoglobulin A (sIgA) levels were significantly increased. In addition, the intestinal microflora was altered by ZEA. Our study showed that ZEA not only caused inflammation of the mucous membrane but also disturbed the microecological balance of the intestine in mice.
format	article
author	Xin Wang Hao Yu Anshan Shan Yongcheng Jin Hengtong Fang Yun Zhao Jinglin Shen Changhai Zhou Yongfeng Zhou Yurong Fu Junmei Wang Jing Zhang
author_facet	Xin Wang Hao Yu Anshan Shan Yongcheng Jin Hengtong Fang Yun Zhao Jinglin Shen Changhai Zhou Yongfeng Zhou Yurong Fu Junmei Wang Jing Zhang
author_sort	Xin Wang
title	Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
title_short	Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
title_full	Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
title_fullStr	Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
title_full_unstemmed	Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice
title_sort	toxic effects of zearalenone on intestinal microflora and intestinal mucosal immunity in mice
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/a10531341ecf459c8399486943fca879
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Toxic effects of Zearalenone on intestinal microflora and intestinal mucosal immunity in mice

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