Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

Riboswitches bind intracellular metabolites and control bacterial gene expression. Here, by using X-ray crystallography, molecular dynamics simulations, and single-molecule fluorescence resonance energy transfer, the authors show how a local Mn2+ ion-binding signal is transduced across the yybP-ykoY...

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Main Authors:	Krishna C. Suddala, Ian R. Price, Shiba S. Dandpat, Michal Janeček, Petra Kührová, Jiří Šponer, Pavel Banáš, Ailong Ke, Nils G. Walter
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/a105e074773f48059aba90c0f77a1c51
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id	oai:doaj.org-article:a105e074773f48059aba90c0f77a1c51
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spelling	oai:doaj.org-article:a105e074773f48059aba90c0f77a1c512021-12-02T16:57:35ZLocal-to-global signal transduction at the core of a Mn2+ sensing riboswitch10.1038/s41467-019-12230-52041-1723https://doaj.org/article/a105e074773f48059aba90c0f77a1c512019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12230-5https://doaj.org/toc/2041-1723Riboswitches bind intracellular metabolites and control bacterial gene expression. Here, by using X-ray crystallography, molecular dynamics simulations, and single-molecule fluorescence resonance energy transfer, the authors show how a local Mn2+ ion-binding signal is transduced across the yybP-ykoY riboswitch from Xanthomonas oryzae.Krishna C. SuddalaIan R. PriceShiba S. DandpatMichal JanečekPetra KührováJiří ŠponerPavel BanášAilong KeNils G. WalterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna C. Suddala Ian R. Price Shiba S. Dandpat Michal Janeček Petra Kührová Jiří Šponer Pavel Banáš Ailong Ke Nils G. Walter Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
description	Riboswitches bind intracellular metabolites and control bacterial gene expression. Here, by using X-ray crystallography, molecular dynamics simulations, and single-molecule fluorescence resonance energy transfer, the authors show how a local Mn2+ ion-binding signal is transduced across the yybP-ykoY riboswitch from Xanthomonas oryzae.
format	article
author	Krishna C. Suddala Ian R. Price Shiba S. Dandpat Michal Janeček Petra Kührová Jiří Šponer Pavel Banáš Ailong Ke Nils G. Walter
author_facet	Krishna C. Suddala Ian R. Price Shiba S. Dandpat Michal Janeček Petra Kührová Jiří Šponer Pavel Banáš Ailong Ke Nils G. Walter
author_sort	Krishna C. Suddala
title	Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
title_short	Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
title_full	Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
title_fullStr	Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
title_full_unstemmed	Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch
title_sort	local-to-global signal transduction at the core of a mn2+ sensing riboswitch
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a105e074773f48059aba90c0f77a1c51
work_keys_str_mv	AT krishnacsuddala localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT ianrprice localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT shibasdandpat localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT michaljanecek localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT petrakuhrova localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT jirisponer localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT pavelbanas localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT ailongke localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch AT nilsgwalter localtoglobalsignaltransductionatthecoreofamn2sensingriboswitch
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Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

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