Mechanism of the inhibitory effect of ghrelin in sepsis

Asha Jacob, Rongqian Wu, Mian Zhou, Gene F Coppa, Ping WangDepartment of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USAAbstract: Sepsis and septic shock are the leading causes of death in intensive...

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Autores principales:	Asha Jacob, Rongqian Wu, Mian Zhou, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/a107e4afd10f49cf90e6449b60aa5743
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spelling	oai:doaj.org-article:a107e4afd10f49cf90e6449b60aa57432021-12-02T01:46:36ZMechanism of the inhibitory effect of ghrelin in sepsis1179-1535https://doaj.org/article/a107e4afd10f49cf90e6449b60aa57432010-02-01T00:00:00Zhttp://www.dovepress.com/mechanism-of-the-inhibitory-effect-of-ghrelin-in-sepsis-a3993https://doaj.org/toc/1179-1535Asha Jacob, Rongqian Wu, Mian Zhou, Gene F Coppa, Ping WangDepartment of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USAAbstract: Sepsis and septic shock are the leading causes of death in intensive care units. Approximately 40%&ndash;70% of the mortality is associated with severe sepsis and septic shock. Systemic antibiotic usage, surgical intervention, aggressive fluid resuscitation and careful monitoring are common measures currently used to treat sepsis. Despite the advances in the understanding of the pathophysiology of sepsis, very little progress has been made towards therapeutic interventions. Recently we have shown that ghrelin, a stomach-derived peptide which is an endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a), is beneficial in attenuating the inflammatory response, organ injury and mortality in an experimental model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). In this review, we describe the mechanism of action of ghrelin in sepsis, highlight the role ghrelin plays in attenuating the hepatic dysfunction induced by sepsis and septic shock and suggest in developing ghrelin as a potential therapy for sepsis.Keywords: ghrelin, sepsis, inhibition septic shock, GHSR-1a, cecal ligation Asha JacobRongqian WuMian Zhouet alDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2010, Iss default, Pp 33-38 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Asha Jacob Rongqian Wu Mian Zhou et al Mechanism of the inhibitory effect of ghrelin in sepsis
description	Asha Jacob, Rongqian Wu, Mian Zhou, Gene F Coppa, Ping WangDepartment of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USAAbstract: Sepsis and septic shock are the leading causes of death in intensive care units. Approximately 40%&ndash;70% of the mortality is associated with severe sepsis and septic shock. Systemic antibiotic usage, surgical intervention, aggressive fluid resuscitation and careful monitoring are common measures currently used to treat sepsis. Despite the advances in the understanding of the pathophysiology of sepsis, very little progress has been made towards therapeutic interventions. Recently we have shown that ghrelin, a stomach-derived peptide which is an endogenous ligand for the growth hormone secretagogue receptor (GHSR-1a), is beneficial in attenuating the inflammatory response, organ injury and mortality in an experimental model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). In this review, we describe the mechanism of action of ghrelin in sepsis, highlight the role ghrelin plays in attenuating the hepatic dysfunction induced by sepsis and septic shock and suggest in developing ghrelin as a potential therapy for sepsis.Keywords: ghrelin, sepsis, inhibition septic shock, GHSR-1a, cecal ligation
format	article
author	Asha Jacob Rongqian Wu Mian Zhou et al
author_facet	Asha Jacob Rongqian Wu Mian Zhou et al
author_sort	Asha Jacob
title	Mechanism of the inhibitory effect of ghrelin in sepsis
title_short	Mechanism of the inhibitory effect of ghrelin in sepsis
title_full	Mechanism of the inhibitory effect of ghrelin in sepsis
title_fullStr	Mechanism of the inhibitory effect of ghrelin in sepsis
title_full_unstemmed	Mechanism of the inhibitory effect of ghrelin in sepsis
title_sort	mechanism of the inhibitory effect of ghrelin in sepsis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/a107e4afd10f49cf90e6449b60aa5743
work_keys_str_mv	AT ashajacob mechanismoftheinhibitoryeffectofghrelininsepsis AT rongqianwu mechanismoftheinhibitoryeffectofghrelininsepsis AT mianzhou mechanismoftheinhibitoryeffectofghrelininsepsis AT etal mechanismoftheinhibitoryeffectofghrelininsepsis
_version_	1718402911337185280

Mechanism of the inhibitory effect of ghrelin in sepsis

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