TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney in...

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Autores principales:	Malika Arhatte, Gihan S. Gunaratne, Charbel El Boustany, Ivana Y. Kuo, Céline Moro, Fabrice Duprat, Magali Plaisant, Hélène Duval, Dahui Li, Nicolas Picard, Anais Couvreux, Christophe Duranton, Isabelle Rubera, Sophie Pagnotta, Sandra Lacas-Gervais, Barbara E. Ehrlich, Jonathan S. Marchant, Aaron M. Savage, Fredericus J. M. van Eeden, Robert N. Wilkinson, Sophie Demolombe, Eric Honoré, Amanda Patel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
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spelling	oai:doaj.org-article:a10e8cca0f764891af20836abbb4891c2021-12-02T14:39:57ZTMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells10.1038/s41467-019-10045-y2041-1723https://doaj.org/article/a10e8cca0f764891af20836abbb4891c2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10045-yhttps://doaj.org/toc/2041-1723Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney injury.Malika ArhatteGihan S. GunaratneCharbel El BoustanyIvana Y. KuoCéline MoroFabrice DupratMagali PlaisantHélène DuvalDahui LiNicolas PicardAnais CouvreuxChristophe DurantonIsabelle RuberaSophie PagnottaSandra Lacas-GervaisBarbara E. EhrlichJonathan S. MarchantAaron M. SavageFredericus J. M. van EedenRobert N. WilkinsonSophie DemolombeEric HonoréAmanda PatelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Malika Arhatte Gihan S. Gunaratne Charbel El Boustany Ivana Y. Kuo Céline Moro Fabrice Duprat Magali Plaisant Hélène Duval Dahui Li Nicolas Picard Anais Couvreux Christophe Duranton Isabelle Rubera Sophie Pagnotta Sandra Lacas-Gervais Barbara E. Ehrlich Jonathan S. Marchant Aaron M. Savage Fredericus J. M. van Eeden Robert N. Wilkinson Sophie Demolombe Eric Honoré Amanda Patel TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
description	Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney injury.
format	article
author	Malika Arhatte Gihan S. Gunaratne Charbel El Boustany Ivana Y. Kuo Céline Moro Fabrice Duprat Magali Plaisant Hélène Duval Dahui Li Nicolas Picard Anais Couvreux Christophe Duranton Isabelle Rubera Sophie Pagnotta Sandra Lacas-Gervais Barbara E. Ehrlich Jonathan S. Marchant Aaron M. Savage Fredericus J. M. van Eeden Robert N. Wilkinson Sophie Demolombe Eric Honoré Amanda Patel
author_facet	Malika Arhatte Gihan S. Gunaratne Charbel El Boustany Ivana Y. Kuo Céline Moro Fabrice Duprat Magali Plaisant Hélène Duval Dahui Li Nicolas Picard Anais Couvreux Christophe Duranton Isabelle Rubera Sophie Pagnotta Sandra Lacas-Gervais Barbara E. Ehrlich Jonathan S. Marchant Aaron M. Savage Fredericus J. M. van Eeden Robert N. Wilkinson Sophie Demolombe Eric Honoré Amanda Patel
author_sort	Malika Arhatte
title	TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
title_short	TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
title_full	TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
title_fullStr	TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
title_full_unstemmed	TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
title_sort	tmem33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a10e8cca0f764891af20836abbb4891c
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_version_	1718390490715389952

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

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