An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.

Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal regio...

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Autores principales:	Jason Vytlacil, Andrew Kayser, Asako Miyakawa, Mark D'Esposito
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a10ea814a3da459a86b529d61cd40f73
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spelling	oai:doaj.org-article:a10ea814a3da459a86b529d61cd40f732021-11-18T08:34:37ZAn approach for identifying brainstem dopaminergic pathways using resting state functional MRI.1932-620310.1371/journal.pone.0087109https://doaj.org/article/a10ea814a3da459a86b529d61cd40f732014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498023/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal region (caudate) that was modulated by both a pharmacological challenge (the administration of the dopaminergic agonist bromocriptine) and a dopamine-sensitive cognitive trait (an individual's working memory capacity). A significant inverted-U shaped connectivity pattern was found in a subset of midbrain-striatal connections, demonstrating that resting state fMRI data is sufficiently powerful to identify brainstem neuromodulatory brain networks.Jason VytlacilAndrew KayserAsako MiyakawaMark D'EspositoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87109 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason Vytlacil Andrew Kayser Asako Miyakawa Mark D'Esposito An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
description	Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal region (caudate) that was modulated by both a pharmacological challenge (the administration of the dopaminergic agonist bromocriptine) and a dopamine-sensitive cognitive trait (an individual's working memory capacity). A significant inverted-U shaped connectivity pattern was found in a subset of midbrain-striatal connections, demonstrating that resting state fMRI data is sufficiently powerful to identify brainstem neuromodulatory brain networks.
format	article
author	Jason Vytlacil Andrew Kayser Asako Miyakawa Mark D'Esposito
author_facet	Jason Vytlacil Andrew Kayser Asako Miyakawa Mark D'Esposito
author_sort	Jason Vytlacil
title	An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
title_short	An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
title_full	An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
title_fullStr	An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
title_full_unstemmed	An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.
title_sort	approach for identifying brainstem dopaminergic pathways using resting state functional mri.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a10ea814a3da459a86b529d61cd40f73
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An approach for identifying brainstem dopaminergic pathways using resting state functional MRI.

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