Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.

<h4>Background</h4>Venous thrombosis is a common disease with a high mortality rate shortly after the event. However, details on long-term mortality in these patients are lacking. The aim of this study was to determine long-term mortality in a large cohort of patients with venous thrombo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Linda E Flinterman, Astrid van Hylckama Vlieg, Suzanne C Cannegieter, Frits R Rosendaal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/a114a10ddc1d49ae8c2418421d680b8f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a114a10ddc1d49ae8c2418421d680b8f
record_format	dspace
spelling	oai:doaj.org-article:a114a10ddc1d49ae8c2418421d680b8f2021-11-18T05:42:24ZLong-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.1549-12771549-167610.1371/journal.pmed.1001155https://doaj.org/article/a114a10ddc1d49ae8c2418421d680b8f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253578/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676<h4>Background</h4>Venous thrombosis is a common disease with a high mortality rate shortly after the event. However, details on long-term mortality in these patients are lacking. The aim of this study was to determine long-term mortality in a large cohort of patients with venous thrombosis.<h4>Methods and findings</h4>4,947 patients from the Multiple Environmental and Genetic Assessment study of risk factors for venous thrombosis (MEGA study) with a first nonfatal venous thrombosis or pulmonary embolism and 6,154 control individuals without venous thrombosis, aged 18 to 70 years, were followed up for 8 years. Death and causes of death were retrieved from the Dutch death registration. Standardized mortality ratios (SMRs) were calculated for patients compared with control individuals. Several subgroups were studied as well. 736 participants (601 patients and 135 controls) died over a follow-up of 54,948 person-years. The overall mortality rate was 22.7 per 1,000 person-years (95% CI 21.0-24.6) for patients and 4.7 per 1,000 person-years (95% CI 4.0-5.6) for controls. Patients with venous thrombosis had a 4.0-fold (95% CI 3.7-4.3) increased risk of death compared with controls. The risk remained increased up to 8 years after the thrombotic event, even when no additional comorbidities were present. The highest risk of death was found for patients with additional malignancies (SMR 5.5, 95% CI 5.0-6.1). Main causes of death were diseases of the circulatory system, venous thrombosis, and malignancies. Main limitation was a maximum age of 70 at time of inclusion for the first event. Therefore results can not be generalized to those in the highest age categories.<h4>Conclusions</h4>Patients who experienced a first venous thrombosis had an increased risk of death which lasted up to 8 years after the event, even when no comorbidities were present at time of thrombosis. Future long-term clinical follow-up could be beneficial in these patients. Please see later in the article for the Editors' Summary.Linda E FlintermanAstrid van Hylckama VliegSuzanne C CannegieterFrits R RosendaalPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 9, Iss 1, p e1001155 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Linda E Flinterman Astrid van Hylckama Vlieg Suzanne C Cannegieter Frits R Rosendaal Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
description	<h4>Background</h4>Venous thrombosis is a common disease with a high mortality rate shortly after the event. However, details on long-term mortality in these patients are lacking. The aim of this study was to determine long-term mortality in a large cohort of patients with venous thrombosis.<h4>Methods and findings</h4>4,947 patients from the Multiple Environmental and Genetic Assessment study of risk factors for venous thrombosis (MEGA study) with a first nonfatal venous thrombosis or pulmonary embolism and 6,154 control individuals without venous thrombosis, aged 18 to 70 years, were followed up for 8 years. Death and causes of death were retrieved from the Dutch death registration. Standardized mortality ratios (SMRs) were calculated for patients compared with control individuals. Several subgroups were studied as well. 736 participants (601 patients and 135 controls) died over a follow-up of 54,948 person-years. The overall mortality rate was 22.7 per 1,000 person-years (95% CI 21.0-24.6) for patients and 4.7 per 1,000 person-years (95% CI 4.0-5.6) for controls. Patients with venous thrombosis had a 4.0-fold (95% CI 3.7-4.3) increased risk of death compared with controls. The risk remained increased up to 8 years after the thrombotic event, even when no additional comorbidities were present. The highest risk of death was found for patients with additional malignancies (SMR 5.5, 95% CI 5.0-6.1). Main causes of death were diseases of the circulatory system, venous thrombosis, and malignancies. Main limitation was a maximum age of 70 at time of inclusion for the first event. Therefore results can not be generalized to those in the highest age categories.<h4>Conclusions</h4>Patients who experienced a first venous thrombosis had an increased risk of death which lasted up to 8 years after the event, even when no comorbidities were present at time of thrombosis. Future long-term clinical follow-up could be beneficial in these patients. Please see later in the article for the Editors' Summary.
format	article
author	Linda E Flinterman Astrid van Hylckama Vlieg Suzanne C Cannegieter Frits R Rosendaal
author_facet	Linda E Flinterman Astrid van Hylckama Vlieg Suzanne C Cannegieter Frits R Rosendaal
author_sort	Linda E Flinterman
title	Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
title_short	Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
title_full	Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
title_fullStr	Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
title_full_unstemmed	Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
title_sort	long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a114a10ddc1d49ae8c2418421d680b8f
work_keys_str_mv	AT lindaeflinterman longtermsurvivalinalargecohortofpatientswithvenousthrombosisincidenceandpredictors AT astridvanhylckamavlieg longtermsurvivalinalargecohortofpatientswithvenousthrombosisincidenceandpredictors AT suzanneccannegieter longtermsurvivalinalargecohortofpatientswithvenousthrombosisincidenceandpredictors AT fritsrrosendaal longtermsurvivalinalargecohortofpatientswithvenousthrombosisincidenceandpredictors
_version_	1718424804470554624

Long-term survival in a large cohort of patients with venous thrombosis: incidence and predictors.

Ejemplares similares