Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morlandet al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain an...
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Nature Portfolio
2017
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oai:doaj.org-article:a11702f00ba142fb867147c82c5434f12021-12-02T17:06:06ZExercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR110.1038/ncomms155572041-1723https://doaj.org/article/a11702f00ba142fb867147c82c5434f12017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15557https://doaj.org/toc/2041-1723Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morlandet al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain angiogenesis.Cecilie MorlandKrister A. AnderssonØyvind P. HaugenAlena HadzicLiv KleppaAndreas GilleJohanne E. RinholmVuk PalibrkElisabeth H. DigetLauritz H. KennedyTomas StølenEivind HennestadOlve MoldestadYiqing CaiMaja PuchadesStefan OffermannsKoen VervaekeMagnar BjøråsUlrik WisløffJon Storm-MathisenLinda H. BergersenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Cecilie Morland Krister A. Andersson Øyvind P. Haugen Alena Hadzic Liv Kleppa Andreas Gille Johanne E. Rinholm Vuk Palibrk Elisabeth H. Diget Lauritz H. Kennedy Tomas Stølen Eivind Hennestad Olve Moldestad Yiqing Cai Maja Puchades Stefan Offermanns Koen Vervaeke Magnar Bjørås Ulrik Wisløff Jon Storm-Mathisen Linda H. Bergersen Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| description |
Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morlandet al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain angiogenesis. |
| format |
article |
| author |
Cecilie Morland Krister A. Andersson Øyvind P. Haugen Alena Hadzic Liv Kleppa Andreas Gille Johanne E. Rinholm Vuk Palibrk Elisabeth H. Diget Lauritz H. Kennedy Tomas Stølen Eivind Hennestad Olve Moldestad Yiqing Cai Maja Puchades Stefan Offermanns Koen Vervaeke Magnar Bjørås Ulrik Wisløff Jon Storm-Mathisen Linda H. Bergersen |
| author_facet |
Cecilie Morland Krister A. Andersson Øyvind P. Haugen Alena Hadzic Liv Kleppa Andreas Gille Johanne E. Rinholm Vuk Palibrk Elisabeth H. Diget Lauritz H. Kennedy Tomas Stølen Eivind Hennestad Olve Moldestad Yiqing Cai Maja Puchades Stefan Offermanns Koen Vervaeke Magnar Bjørås Ulrik Wisløff Jon Storm-Mathisen Linda H. Bergersen |
| author_sort |
Cecilie Morland |
| title |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| title_short |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| title_full |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| title_fullStr |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| title_full_unstemmed |
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 |
| title_sort |
exercise induces cerebral vegf and angiogenesis via the lactate receptor hcar1 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a11702f00ba142fb867147c82c5434f1 |
| work_keys_str_mv |
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