A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs
Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.
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Nature Portfolio
2016
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oai:doaj.org-article:a11a26eb638c455b881f87794f4e9c132021-12-02T15:34:30ZA human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs10.1038/ncomms113202041-1723https://doaj.org/article/a11a26eb638c455b881f87794f4e9c132016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11320https://doaj.org/toc/2041-1723Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection.Alexander KarlasStefano BerreThérèse CoudercMargus VarjakPeter BraunMichael MeyerNicolas GangneuxLiis Karo-AstoverFriderike WeegeMartin RafteryGünther SchönrichUwe KlemmAnne WurzlbauerFranz BracherAndres MeritsThomas F. MeyerMarc LecuitNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| description |
Chikungunya virus is a mosquito transmitted untreatable emergent pathogen that causes joint pain and fever. Here the authors perform a host genome-wide loss-of-function screen to identify targets for chikungunya antiviral drugs and validate hits using a mouse model of chikungunya infection. |
| format |
article |
| author |
Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit |
| author_facet |
Alexander Karlas Stefano Berre Thérèse Couderc Margus Varjak Peter Braun Michael Meyer Nicolas Gangneux Liis Karo-Astover Friderike Weege Martin Raftery Günther Schönrich Uwe Klemm Anne Wurzlbauer Franz Bracher Andres Merits Thomas F. Meyer Marc Lecuit |
| author_sort |
Alexander Karlas |
| title |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_short |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_full |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_fullStr |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_full_unstemmed |
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| title_sort |
human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/a11a26eb638c455b881f87794f4e9c13 |
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