TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

EGF receptor (EGFR) amplification and mutation are major drivers in glioma tumorigenesis but this mechanism is not well understood. Here, the authors show EGFR-upregulated H3K23ac binds TRIM24 which recruits STAT3, leading to activation of STAT3 signaling, enhancing EGFR-driven tumorigenesis.

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Autores principales:	Deguan Lv, Yanxin Li, Weiwei Zhang, Angel A. Alvarez, Lina Song, Jianming Tang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Haizhong Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a11ad2bfdbda4f98b174d299a4358295
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spelling	oai:doaj.org-article:a11ad2bfdbda4f98b174d299a43582952021-12-02T14:42:03ZTRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma10.1038/s41467-017-01731-w2041-1723https://doaj.org/article/a11ad2bfdbda4f98b174d299a43582952017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01731-whttps://doaj.org/toc/2041-1723EGF receptor (EGFR) amplification and mutation are major drivers in glioma tumorigenesis but this mechanism is not well understood. Here, the authors show EGFR-upregulated H3K23ac binds TRIM24 which recruits STAT3, leading to activation of STAT3 signaling, enhancing EGFR-driven tumorigenesis.Deguan LvYanxin LiWeiwei ZhangAngel A. AlvarezLina SongJianming TangWei-Qiang GaoBo HuShi-Yuan ChengHaizhong FengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deguan Lv Yanxin Li Weiwei Zhang Angel A. Alvarez Lina Song Jianming Tang Wei-Qiang Gao Bo Hu Shi-Yuan Cheng Haizhong Feng TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
description	EGF receptor (EGFR) amplification and mutation are major drivers in glioma tumorigenesis but this mechanism is not well understood. Here, the authors show EGFR-upregulated H3K23ac binds TRIM24 which recruits STAT3, leading to activation of STAT3 signaling, enhancing EGFR-driven tumorigenesis.
format	article
author	Deguan Lv Yanxin Li Weiwei Zhang Angel A. Alvarez Lina Song Jianming Tang Wei-Qiang Gao Bo Hu Shi-Yuan Cheng Haizhong Feng
author_facet	Deguan Lv Yanxin Li Weiwei Zhang Angel A. Alvarez Lina Song Jianming Tang Wei-Qiang Gao Bo Hu Shi-Yuan Cheng Haizhong Feng
author_sort	Deguan Lv
title	TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
title_short	TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
title_full	TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
title_fullStr	TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
title_full_unstemmed	TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma
title_sort	trim24 is an oncogenic transcriptional co-activator of stat3 in glioblastoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a11ad2bfdbda4f98b174d299a4358295
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TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

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