TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

EGF receptor (EGFR) amplification and mutation are major drivers in glioma tumorigenesis but this mechanism is not well understood. Here, the authors show EGFR-upregulated H3K23ac binds TRIM24 which recruits STAT3, leading to activation of STAT3 signaling, enhancing EGFR-driven tumorigenesis.

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Detalles Bibliográficos
Autores principales: Deguan Lv, Yanxin Li, Weiwei Zhang, Angel A. Alvarez, Lina Song, Jianming Tang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Haizhong Feng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/a11ad2bfdbda4f98b174d299a4358295
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