The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C-inhibitory mechanism in addition to MCC activity.

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Autores principales:	Luying Jia, Bing Li, Hongtao Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a11f539f05294ccbbba855d6a5043053
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spelling	oai:doaj.org-article:a11f539f05294ccbbba855d6a50430532021-12-02T15:34:55ZThe Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation10.1038/ncomms108182041-1723https://doaj.org/article/a11f539f05294ccbbba855d6a50430532016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10818https://doaj.org/toc/2041-1723The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C-inhibitory mechanism in addition to MCC activity.Luying JiaBing LiHongtao YuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luying Jia Bing Li Hongtao Yu The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
description	The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C-inhibitory mechanism in addition to MCC activity.
format	article
author	Luying Jia Bing Li Hongtao Yu
author_facet	Luying Jia Bing Li Hongtao Yu
author_sort	Luying Jia
title	The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
title_short	The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
title_full	The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
title_fullStr	The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
title_full_unstemmed	The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
title_sort	bub1–plk1 kinase complex promotes spindle checkpoint signalling through cdc20 phosphorylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a11f539f05294ccbbba855d6a5043053
work_keys_str_mv	AT luyingjia thebub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation AT bingli thebub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation AT hongtaoyu thebub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation AT luyingjia bub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation AT bingli bub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation AT hongtaoyu bub1plk1kinasecomplexpromotesspindlecheckpointsignallingthroughcdc20phosphorylation
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The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

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