Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease

Takahiko Hayashi1, Misaki Ishioka2, Norihiko Ito1, Yoko Kato1, Hisashi Nakagawa3, Hiroshi Hatano4, Nobuhisa Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Ryogoku Eye Clinic, Tokyo, Japan; 3Tokushima Eye Clinic, Higashimurayama-shi, Toky...

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Autores principales:	Takahiko Hayashi, Misaki Ishioka, Norihiko Ito, Yoko Kato, Hisashi Nakagawa, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a12230c98f4e4b63a0c4a08113563473
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spelling	oai:doaj.org-article:a12230c98f4e4b63a0c4a081135634732021-12-02T00:48:48ZBilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease1177-54671177-5483https://doaj.org/article/a12230c98f4e4b63a0c4a081135634732008-06-01T00:00:00Zhttp://www.dovepress.com/bilateral-herpes-simplex-keratitis-in-a-patient-with-chronic-graft-ver-a1801https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Takahiko Hayashi1, Misaki Ishioka2, Norihiko Ito1, Yoko Kato1, Hisashi Nakagawa3, Hiroshi Hatano4, Nobuhisa Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Ryogoku Eye Clinic, Tokyo, Japan; 3Tokushima Eye Clinic, Higashimurayama-shi, Tokyo, Japan; 4Lumine Hatano Eye Clinic, Fujisawa, Fujisawa-shi, Kanagawa, JapanPurpose: To describe a case of bilateral herpes simplex keratitis accompanying chronic graft-versus-host disease (GVHD).Design: Observational case report.Case report: An 11-year-old boy with myelocytic leukemia underwent allogeneic bone marrow transplantation. He developed symptoms of the skin, eyes, and mouth, and lip biopsy indicated chronic GVHD. Persistent keratitis with corneal filaments and neovascularization was noted in both eyes. Sodium hyaluronate, autoserum, and 0.1% fluorometholone eyedrops were instilled for approximately 2 years to treat this keratitis, and there were no other ocular changes. Bilateral herpes simplex keratitis developed with geographic ulcers after topical betamethasone therapy, but responded to acyclovir ointment.Conclusions: Herpes keratitis should be considered in the differential diagnosis of bilateral keratitis in patients with reduced immunocompetence. During the course of chronic GVHD, corneal herpes may occur, so ocular treatment with topical corticosteroids should be managed by an ophthalmologist to monitor sight-threatening conditions such as corneal herpes.Keywords: chronic graft-versus-host disease, bone marrow transplant, corneal herpes, bilateral herpes simplex keratitis, dry eyes Takahiko HayashiMisaki IshiokaNorihiko ItoYoko KatoHisashi Nakagawaet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 2, Pp 457-459 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Takahiko Hayashi Misaki Ishioka Norihiko Ito Yoko Kato Hisashi Nakagawa et al Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
description	Takahiko Hayashi1, Misaki Ishioka2, Norihiko Ito1, Yoko Kato1, Hisashi Nakagawa3, Hiroshi Hatano4, Nobuhisa Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Ryogoku Eye Clinic, Tokyo, Japan; 3Tokushima Eye Clinic, Higashimurayama-shi, Tokyo, Japan; 4Lumine Hatano Eye Clinic, Fujisawa, Fujisawa-shi, Kanagawa, JapanPurpose: To describe a case of bilateral herpes simplex keratitis accompanying chronic graft-versus-host disease (GVHD).Design: Observational case report.Case report: An 11-year-old boy with myelocytic leukemia underwent allogeneic bone marrow transplantation. He developed symptoms of the skin, eyes, and mouth, and lip biopsy indicated chronic GVHD. Persistent keratitis with corneal filaments and neovascularization was noted in both eyes. Sodium hyaluronate, autoserum, and 0.1% fluorometholone eyedrops were instilled for approximately 2 years to treat this keratitis, and there were no other ocular changes. Bilateral herpes simplex keratitis developed with geographic ulcers after topical betamethasone therapy, but responded to acyclovir ointment.Conclusions: Herpes keratitis should be considered in the differential diagnosis of bilateral keratitis in patients with reduced immunocompetence. During the course of chronic GVHD, corneal herpes may occur, so ocular treatment with topical corticosteroids should be managed by an ophthalmologist to monitor sight-threatening conditions such as corneal herpes.Keywords: chronic graft-versus-host disease, bone marrow transplant, corneal herpes, bilateral herpes simplex keratitis, dry eyes
format	article
author	Takahiko Hayashi Misaki Ishioka Norihiko Ito Yoko Kato Hisashi Nakagawa et al
author_facet	Takahiko Hayashi Misaki Ishioka Norihiko Ito Yoko Kato Hisashi Nakagawa et al
author_sort	Takahiko Hayashi
title	Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
title_short	Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
title_full	Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
title_fullStr	Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
title_full_unstemmed	Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
title_sort	bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a12230c98f4e4b63a0c4a08113563473
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_version_	1718403456527499264

Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease

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