Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials

Background: Previous investigations have proposed that the consumption of infant formula supplemented with prebiotics, probiotics and synbiotics (PRO-formula) may have protective impacts on respiratory tract infections (RTIs). Nevertheless, the findings of studies are contradictory. This meta-analys...

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Autores principales:	Kamil Rashidi, Mina Darand, Nazila Garousi, Azadeh Dehghani, Shahab Alizadeh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Probiotics Prebiotics Synbiotics Formula Respiratory tract infections Meta-analysis Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/a12392676d864d96bda401659039e5c9
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spelling	oai:doaj.org-article:a12392676d864d96bda401659039e5c92021-12-02T04:59:15ZEffect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials0965-229910.1016/j.ctim.2021.102795https://doaj.org/article/a12392676d864d96bda401659039e5c92021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0965229921001369https://doaj.org/toc/0965-2299Background: Previous investigations have proposed that the consumption of infant formula supplemented with prebiotics, probiotics and synbiotics (PRO-formula) may have protective impacts on respiratory tract infections (RTIs). Nevertheless, the findings of studies are contradictory. This meta-analysis aimed to explore the influence of PRO-formula on RTIs in infants by pooling randomized controlled trials (RCTs). Methods: To obtain eligible RCTs, Scopus and PubMed databases were systematically searched from their inception to November 2020. A random-effects model was applied to pool the relative risks (RR) and corresponding 95% confidence intervals (CI) for RTIs following consumption of PRO-formula. Results: A total of 15 RCTs, with a total sample size of 3805 participants (1957 for intervention and 1848 for placebo), were included in the present meta-analysis. In the overall analysis, in comparison to placebo, consumption of PRO-formula had a significant protective impact against RTIs (RR = 0.89, 95%CI: 0.82–0.97) in infants, with a remarkable evidence of heterogeneity across studies (I2 = 61.4%, P < 0.001). In the meta-regression analysis, the effect of PRO-formula on RTIs was not modified by the follow-up duration. No evidence for publication bias was detected. Conclusions: Administration of PRO-formula may be a potential approach for the prevention of respiratory tract infections in infants.Kamil RashidiMina DarandNazila GarousiAzadeh DehghaniShahab AlizadehElsevierarticleProbioticsPrebioticsSynbioticsFormulaRespiratory tract infectionsMeta-analysisOther systems of medicineRZ201-999ENComplementary Therapies in Medicine, Vol 63, Iss , Pp 102795- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Probiotics Prebiotics Synbiotics Formula Respiratory tract infections Meta-analysis Other systems of medicine RZ201-999
spellingShingle	Probiotics Prebiotics Synbiotics Formula Respiratory tract infections Meta-analysis Other systems of medicine RZ201-999 Kamil Rashidi Mina Darand Nazila Garousi Azadeh Dehghani Shahab Alizadeh Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
description	Background: Previous investigations have proposed that the consumption of infant formula supplemented with prebiotics, probiotics and synbiotics (PRO-formula) may have protective impacts on respiratory tract infections (RTIs). Nevertheless, the findings of studies are contradictory. This meta-analysis aimed to explore the influence of PRO-formula on RTIs in infants by pooling randomized controlled trials (RCTs). Methods: To obtain eligible RCTs, Scopus and PubMed databases were systematically searched from their inception to November 2020. A random-effects model was applied to pool the relative risks (RR) and corresponding 95% confidence intervals (CI) for RTIs following consumption of PRO-formula. Results: A total of 15 RCTs, with a total sample size of 3805 participants (1957 for intervention and 1848 for placebo), were included in the present meta-analysis. In the overall analysis, in comparison to placebo, consumption of PRO-formula had a significant protective impact against RTIs (RR = 0.89, 95%CI: 0.82–0.97) in infants, with a remarkable evidence of heterogeneity across studies (I2 = 61.4%, P < 0.001). In the meta-regression analysis, the effect of PRO-formula on RTIs was not modified by the follow-up duration. No evidence for publication bias was detected. Conclusions: Administration of PRO-formula may be a potential approach for the prevention of respiratory tract infections in infants.
format	article
author	Kamil Rashidi Mina Darand Nazila Garousi Azadeh Dehghani Shahab Alizadeh
author_facet	Kamil Rashidi Mina Darand Nazila Garousi Azadeh Dehghani Shahab Alizadeh
author_sort	Kamil Rashidi
title	Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
title_short	Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
title_full	Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
title_fullStr	Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
title_full_unstemmed	Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials
title_sort	effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: a systematic review and meta-analysis of randomized clinical trials
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a12392676d864d96bda401659039e5c9
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Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials

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