Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic ta...

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Autores principales:	Justin T. Hsieh, Abhay P. S. Rathore, Gayathri Soundarajan, Ashley L. St. John
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1252673e59a4b52965206e11b5c4bc2
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spelling	oai:doaj.org-article:a1252673e59a4b52965206e11b5c4bc22021-12-02T17:01:45ZJapanese encephalitis virus neuropenetrance is driven by mast cell chymase10.1038/s41467-019-08641-z2041-1723https://doaj.org/article/a1252673e59a4b52965206e11b5c4bc22019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08641-zhttps://doaj.org/toc/2041-1723How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic target.Justin T. HsiehAbhay P. S. RathoreGayathri SoundarajanAshley L. St. JohnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin T. Hsieh Abhay P. S. Rathore Gayathri Soundarajan Ashley L. St. John Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
description	How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic target.
format	article
author	Justin T. Hsieh Abhay P. S. Rathore Gayathri Soundarajan Ashley L. St. John
author_facet	Justin T. Hsieh Abhay P. S. Rathore Gayathri Soundarajan Ashley L. St. John
author_sort	Justin T. Hsieh
title	Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
title_short	Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
title_full	Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
title_fullStr	Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
title_full_unstemmed	Japanese encephalitis virus neuropenetrance is driven by mast cell chymase
title_sort	japanese encephalitis virus neuropenetrance is driven by mast cell chymase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a1252673e59a4b52965206e11b5c4bc2
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Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

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