Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic ta...

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Autores principales: Justin T. Hsieh, Abhay P. S. Rathore, Gayathri Soundarajan, Ashley L. St. John
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/a1252673e59a4b52965206e11b5c4bc2
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