$Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings$
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Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings

Abstract Multifocus microscopy (MFM) allows sensitive and fast three-dimensional imaging. It relies on the efficient design of diffraction phase gratings yielding homogeneous intensities in desired diffraction orders. Such performances are however guaranteed only for a specific wavelength. Here, we...

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Autores principales:	Bassam Hajj, Laura Oudjedi, Jean-Bernard Fiche, Maxime Dahan, Marcelo Nollmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1264e73eae546be85f0b386585d040d
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spelling	oai:doaj.org-article:a1264e73eae546be85f0b386585d040d2021-12-02T12:32:16ZHighly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings10.1038/s41598-017-05531-62045-2322https://doaj.org/article/a1264e73eae546be85f0b386585d040d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05531-6https://doaj.org/toc/2045-2322Abstract Multifocus microscopy (MFM) allows sensitive and fast three-dimensional imaging. It relies on the efficient design of diffraction phase gratings yielding homogeneous intensities in desired diffraction orders. Such performances are however guaranteed only for a specific wavelength. Here, we discuss a novel approach for designing binary phase gratings with dual color properties and improved diffraction efficiency for MFM. We simulate binary diffraction gratings with tunable phase shifts to explore its best diffraction performances. We report the design and fabrication of a binary array generator of 3 × 3 equal-intensity diffraction orders with 74% efficiency, 95% uniformity and dual color capability. The multicolor properties of this new design are highlighted by two-color MFM imaging. Finally, we discuss the basics of extending this approach to a variety of diffraction pattern designs.Bassam HajjLaura OudjediJean-Bernard FicheMaxime DahanMarcelo NollmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bassam Hajj Laura Oudjedi Jean-Bernard Fiche Maxime Dahan Marcelo Nollmann Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
description	Abstract Multifocus microscopy (MFM) allows sensitive and fast three-dimensional imaging. It relies on the efficient design of diffraction phase gratings yielding homogeneous intensities in desired diffraction orders. Such performances are however guaranteed only for a specific wavelength. Here, we discuss a novel approach for designing binary phase gratings with dual color properties and improved diffraction efficiency for MFM. We simulate binary diffraction gratings with tunable phase shifts to explore its best diffraction performances. We report the design and fabrication of a binary array generator of 3 × 3 equal-intensity diffraction orders with 74% efficiency, 95% uniformity and dual color capability. The multicolor properties of this new design are highlighted by two-color MFM imaging. Finally, we discuss the basics of extending this approach to a variety of diffraction pattern designs.
format	article
author	Bassam Hajj Laura Oudjedi Jean-Bernard Fiche Maxime Dahan Marcelo Nollmann
author_facet	Bassam Hajj Laura Oudjedi Jean-Bernard Fiche Maxime Dahan Marcelo Nollmann
author_sort	Bassam Hajj
title	Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
title_short	Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
title_full	Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
title_fullStr	Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
title_full_unstemmed	Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
title_sort	highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a1264e73eae546be85f0b386585d040d
work_keys_str_mv	AT bassamhajj highlyefficientmulticolormultifocusmicroscopybyoptimaldesignofdiffractionbinarygratings AT lauraoudjedi highlyefficientmulticolormultifocusmicroscopybyoptimaldesignofdiffractionbinarygratings AT jeanbernardfiche highlyefficientmulticolormultifocusmicroscopybyoptimaldesignofdiffractionbinarygratings AT maximedahan highlyefficientmulticolormultifocusmicroscopybyoptimaldesignofdiffractionbinarygratings AT marcelonollmann highlyefficientmulticolormultifocusmicroscopybyoptimaldesignofdiffractionbinarygratings
_version_	1718394110723751936

Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings

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