Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation

Imiquimod exacerbates IL-23-induced skin inflammation and models psoriasis in mice. Here the authors show that this pathology is not dependent on resident dendritic cells, but on CCR6-induced immigration of monocyte-derived cells.

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Detalles Bibliográficos
Autores principales: Tej Pratap Singh, Howard H. Zhang, Izabela Borek, Peter Wolf, Michael N. Hedrick, Satya P. Singh, Brian L. Kelsall, Bjorn E. Clausen, Joshua M. Farber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a126aabdb97548dbabecf0921d638839
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Sumario:Imiquimod exacerbates IL-23-induced skin inflammation and models psoriasis in mice. Here the authors show that this pathology is not dependent on resident dendritic cells, but on CCR6-induced immigration of monocyte-derived cells.