Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis

Abstract Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and hydr...

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Autores principales:	Ana Lívia Libardi Bertachini, Gabriela Cintra Januario, Sergio Luiz Novi, Rickson Coelho Mesquita, Marco Aurélio Romano Silva, Gláucia Manzan Queiroz Andrade, Luciana Macedo de Resende, Débora Marques de Miranda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1291c582d114d60b9dc7ccc803f2744
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spelling	oai:doaj.org-article:a1291c582d114d60b9dc7ccc803f27442021-12-02T17:15:32ZHearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis10.1038/s41598-021-89481-02045-2322https://doaj.org/article/a1291c582d114d60b9dc7ccc803f27442021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89481-0https://doaj.org/toc/2045-2322Abstract Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and hydrocephalus are common. In this study, we aimed to evaluate the brain evoked hemodynamic responses of CT and healthy infants during four auditory stimuli: mother infant directed speech, researcher infant directed speech, mother reading and researcher recorded. Children underwent Transitionally Evoked Otoacoustic Emission Auditory Testing and Automated Brainstem Auditory Response tests with normal auditory results, but with a tendency for greater latencies in the CT group compared to the control group. We assessed brain hemodynamics with functional near-infrared spectroscopy (fNIRS) measurements from 61 infants, and we present fNIRS results as frequency maps of activation and deactivation for each stimulus. By evaluating infants in the three first months of life, we observed an individual heterogeneous brain activation pattern in response to all auditory stimuli for both groups. Each channel was activated or deactivated in less than 30% of children for all stimuli. There is a need of prospective studies to evaluate if the neurologic or auditory changes course with compromise of children outcomes.Ana Lívia Libardi BertachiniGabriela Cintra JanuarioSergio Luiz NoviRickson Coelho MesquitaMarco Aurélio Romano SilvaGláucia Manzan Queiroz AndradeLuciana Macedo de ResendeDébora Marques de MirandaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Lívia Libardi Bertachini Gabriela Cintra Januario Sergio Luiz Novi Rickson Coelho Mesquita Marco Aurélio Romano Silva Gláucia Manzan Queiroz Andrade Luciana Macedo de Resende Débora Marques de Miranda Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
description	Abstract Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and hydrocephalus are common. In this study, we aimed to evaluate the brain evoked hemodynamic responses of CT and healthy infants during four auditory stimuli: mother infant directed speech, researcher infant directed speech, mother reading and researcher recorded. Children underwent Transitionally Evoked Otoacoustic Emission Auditory Testing and Automated Brainstem Auditory Response tests with normal auditory results, but with a tendency for greater latencies in the CT group compared to the control group. We assessed brain hemodynamics with functional near-infrared spectroscopy (fNIRS) measurements from 61 infants, and we present fNIRS results as frequency maps of activation and deactivation for each stimulus. By evaluating infants in the three first months of life, we observed an individual heterogeneous brain activation pattern in response to all auditory stimuli for both groups. Each channel was activated or deactivated in less than 30% of children for all stimuli. There is a need of prospective studies to evaluate if the neurologic or auditory changes course with compromise of children outcomes.
format	article
author	Ana Lívia Libardi Bertachini Gabriela Cintra Januario Sergio Luiz Novi Rickson Coelho Mesquita Marco Aurélio Romano Silva Gláucia Manzan Queiroz Andrade Luciana Macedo de Resende Débora Marques de Miranda
author_facet	Ana Lívia Libardi Bertachini Gabriela Cintra Januario Sergio Luiz Novi Rickson Coelho Mesquita Marco Aurélio Romano Silva Gláucia Manzan Queiroz Andrade Luciana Macedo de Resende Débora Marques de Miranda
author_sort	Ana Lívia Libardi Bertachini
title	Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
title_short	Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
title_full	Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
title_fullStr	Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
title_full_unstemmed	Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
title_sort	hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1291c582d114d60b9dc7ccc803f2744
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Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis

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