Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer

Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival...

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Autores principales:	Corrado Pedrazzani, Guido Mantovani, Eduardo Fernandes, Fabio Bagante, Gian Luca Salvagno, Niccolò Surci, Tommaso Campagnaro, Andrea Ruzzenente, Elisa Danese, Giuseppe Lippi, Alfredo Guglielmi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a12a16f843aa40acb704d1d4b36b82fd
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spelling	oai:doaj.org-article:a12a16f843aa40acb704d1d4b36b82fd2021-12-02T16:06:36ZAssessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer10.1038/s41598-017-01652-02045-2322https://doaj.org/article/a12a16f843aa40acb704d1d4b36b82fd2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01652-0https://doaj.org/toc/2045-2322Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal cancer (CRC). Receiver operating characteristic (ROC) curve analysis was performed to define cut-off values for high and low ratios of these indices. Univariate and multivariate analysis were used to determine the prognostic value of NLR, PLR and PC for overall and cancer-related survival. The distribution of NLR, PLR and PC in CRC patients was compared with 5270 healthy blood donors. The distribution of NLR, PLR and PC was significantly different between CRC patients and controls (all p < 0.05). A significant but heterogeneous association was found between the main CRC prognostic factors and high values of NLR, PLR and PC. Survival appeared to be worse in patients with high NLR with cancers in AJCC/UICC TNM Stages I-IV; nonetheless its prognostic value was not confirmed for cancer-related survival in multivariate analysis. After stratification of patients according to AJCC/UICC TNM stages, high PC value was significantly correlated with overall and cancer-related survival in TNM stage IV patients.Corrado PedrazzaniGuido MantovaniEduardo FernandesFabio BaganteGian Luca SalvagnoNiccolò SurciTommaso CampagnaroAndrea RuzzenenteElisa DaneseGiuseppe LippiAlfredo GuglielmiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
description	Abstract Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal cancer (CRC). Receiver operating characteristic (ROC) curve analysis was performed to define cut-off values for high and low ratios of these indices. Univariate and multivariate analysis were used to determine the prognostic value of NLR, PLR and PC for overall and cancer-related survival. The distribution of NLR, PLR and PC in CRC patients was compared with 5270 healthy blood donors. The distribution of NLR, PLR and PC was significantly different between CRC patients and controls (all p < 0.05). A significant but heterogeneous association was found between the main CRC prognostic factors and high values of NLR, PLR and PC. Survival appeared to be worse in patients with high NLR with cancers in AJCC/UICC TNM Stages I-IV; nonetheless its prognostic value was not confirmed for cancer-related survival in multivariate analysis. After stratification of patients according to AJCC/UICC TNM stages, high PC value was significantly correlated with overall and cancer-related survival in TNM stage IV patients.
format	article
author	Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi
author_facet	Corrado Pedrazzani Guido Mantovani Eduardo Fernandes Fabio Bagante Gian Luca Salvagno Niccolò Surci Tommaso Campagnaro Andrea Ruzzenente Elisa Danese Giuseppe Lippi Alfredo Guglielmi
author_sort	Corrado Pedrazzani
title	Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
title_short	Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
title_full	Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
title_fullStr	Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
title_full_unstemmed	Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer
title_sort	assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after r0 resection for colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a12a16f843aa40acb704d1d4b36b82fd
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Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer

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