Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials

The dissolution of atorvastatin calcium need to be improved since included BCS Class II drugs with low solubility and high permeability, meaning that the dissolution affects the bioavailability of drugs. This research aimed to develop a formulation of a liquisolid tablet using PEG 400 as a solvent a...

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Autores principales:	Yulias Ninik Windriyati, Matsniyyatul Badriyah, Diar Arum Kusumaningtyas, Rian Lesta Riesmalia
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	atorvastatin calcium dissolution liquisolid tablets polyethylene glycol 400 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/a12ab8d976c44e03a598544f8d0089af
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spelling	oai:doaj.org-article:a12ab8d976c44e03a598544f8d0089af2021-11-15T06:08:47ZLiquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials2338-94272338-948610.22146/ijp.1138https://doaj.org/article/a12ab8d976c44e03a598544f8d0089af2020-12-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1138https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486The dissolution of atorvastatin calcium need to be improved since included BCS Class II drugs with low solubility and high permeability, meaning that the dissolution affects the bioavailability of drugs. This research aimed to develop a formulation of a liquisolid tablet using PEG 400 as a solvent and some carrier materials in various compositions to increase the dissolution of atorvastatin calcium. Different formulations of liquisolid tablets were conducted using different quantities of carrier and coating material for adsorbing liquid solvent to produce a free-flowing and compressible powder. Avicel PH 101, Avicel PH 102, Neusilin US2 were employed as the carrier and Aerosil 200 as the coating material. A disintegrant and lubricant were then added to the formed liquisolid system and compressed into tablets by the direct compressing method. The liquisolid tablets were characterized for their tableting properties and possible drug-excipient interaction by XRD and FTIR analysis. The tableting characteristics of atorvastatin calcium liquisolid tablets were within the acceptable limits criteria. The dissolution of AA4 and NA1 liquisolid tablets was higher compared to marketed tablets. Based on the XRD and FTIR analysis, no interactions between drug and excipient.Yulias Ninik WindriyatiMatsniyyatul BadriyahDiar Arum KusumaningtyasRian Lesta RiesmaliaUniversitas Gadjah Madaarticleatorvastatin calciumdissolutionliquisolid tabletspolyethylene glycol 400Pharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 305–311-305–311 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	atorvastatin calcium dissolution liquisolid tablets polyethylene glycol 400 Pharmacy and materia medica RS1-441
spellingShingle	atorvastatin calcium dissolution liquisolid tablets polyethylene glycol 400 Pharmacy and materia medica RS1-441 Yulias Ninik Windriyati Matsniyyatul Badriyah Diar Arum Kusumaningtyas Rian Lesta Riesmalia Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
description	The dissolution of atorvastatin calcium need to be improved since included BCS Class II drugs with low solubility and high permeability, meaning that the dissolution affects the bioavailability of drugs. This research aimed to develop a formulation of a liquisolid tablet using PEG 400 as a solvent and some carrier materials in various compositions to increase the dissolution of atorvastatin calcium. Different formulations of liquisolid tablets were conducted using different quantities of carrier and coating material for adsorbing liquid solvent to produce a free-flowing and compressible powder. Avicel PH 101, Avicel PH 102, Neusilin US2 were employed as the carrier and Aerosil 200 as the coating material. A disintegrant and lubricant were then added to the formed liquisolid system and compressed into tablets by the direct compressing method. The liquisolid tablets were characterized for their tableting properties and possible drug-excipient interaction by XRD and FTIR analysis. The tableting characteristics of atorvastatin calcium liquisolid tablets were within the acceptable limits criteria. The dissolution of AA4 and NA1 liquisolid tablets was higher compared to marketed tablets. Based on the XRD and FTIR analysis, no interactions between drug and excipient.
format	article
author	Yulias Ninik Windriyati Matsniyyatul Badriyah Diar Arum Kusumaningtyas Rian Lesta Riesmalia
author_facet	Yulias Ninik Windriyati Matsniyyatul Badriyah Diar Arum Kusumaningtyas Rian Lesta Riesmalia
author_sort	Yulias Ninik Windriyati
title	Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
title_short	Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
title_full	Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
title_fullStr	Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
title_full_unstemmed	Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials
title_sort	liquisolid tablets formulation of atorvastatin calcium using polyethylene glycol 400 as solvent and some carrier materials
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/a12ab8d976c44e03a598544f8d0089af
work_keys_str_mv	AT yuliasninikwindriyati liquisolidtabletsformulationofatorvastatincalciumusingpolyethyleneglycol400assolventandsomecarriermaterials AT matsniyyatulbadriyah liquisolidtabletsformulationofatorvastatincalciumusingpolyethyleneglycol400assolventandsomecarriermaterials AT diararumkusumaningtyas liquisolidtabletsformulationofatorvastatincalciumusingpolyethyleneglycol400assolventandsomecarriermaterials AT rianlestariesmalia liquisolidtabletsformulationofatorvastatincalciumusingpolyethyleneglycol400assolventandsomecarriermaterials
_version_	1718428571725201408

Liquisolid Tablets Formulation of Atorvastatin Calcium Using Polyethylene Glycol 400 as Solvent and Some Carrier Materials

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