Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a conventional component in Chinese medicine, and is c...

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Autores principales:	Tan W, Li YB, Chen MW, Wang YT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a12cfe643ba3453d8fb05ee2fd434ccf
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spelling	oai:doaj.org-article:a12cfe643ba3453d8fb05ee2fd434ccf2021-12-02T02:44:05ZBerberine hydrochloride: anticancer activity and nanoparticulate delivery system1176-91141178-2013https://doaj.org/article/a12cfe643ba3453d8fb05ee2fd434ccf2011-08-01T00:00:00Zhttp://www.dovepress.com/berberine-hydrochloride-anticancer-activity-and-nanoparticulate-delive-a8140https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine.Methods and results: We accessed conventional databases, such as PubMed, Scope, and Web of Science, using &ldquo;berberine hydrochloride&rdquo;, &ldquo;anti-cancer mechanism&rdquo;, and &ldquo;nanoparticulate delivery system&rdquo; as search words, then summarized the progress in research, illustrating the need to explore reprogramming of cancer cell metabolism using nanoparticulate drug delivery systems.Conclusion: With increasing research on regulation of cancer cell metabolism by berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation.Keywords: berberine hydrochloride, anticancer mechanisms, nanoparticulate drug progressTan WLi YBChen MWWang YTDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1773-1777 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tan W Li YB Chen MW Wang YT Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
description	Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine.Methods and results: We accessed conventional databases, such as PubMed, Scope, and Web of Science, using &ldquo;berberine hydrochloride&rdquo;, &ldquo;anti-cancer mechanism&rdquo;, and &ldquo;nanoparticulate delivery system&rdquo; as search words, then summarized the progress in research, illustrating the need to explore reprogramming of cancer cell metabolism using nanoparticulate drug delivery systems.Conclusion: With increasing research on regulation of cancer cell metabolism by berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation.Keywords: berberine hydrochloride, anticancer mechanisms, nanoparticulate drug progress
format	article
author	Tan W Li YB Chen MW Wang YT
author_facet	Tan W Li YB Chen MW Wang YT
author_sort	Tan W
title	Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
title_short	Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
title_full	Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
title_fullStr	Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
title_full_unstemmed	Berberine hydrochloride: anticancer activity and nanoparticulate delivery system
title_sort	berberine hydrochloride: anticancer activity and nanoparticulate delivery system
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/a12cfe643ba3453d8fb05ee2fd434ccf
work_keys_str_mv	AT tanw berberinehydrochlorideanticanceractivityandnanoparticulatedeliverysystem AT liyb berberinehydrochlorideanticanceractivityandnanoparticulatedeliverysystem AT chenmw berberinehydrochlorideanticanceractivityandnanoparticulatedeliverysystem AT wangyt berberinehydrochlorideanticanceractivityandnanoparticulatedeliverysystem
_version_	1718402181189599232

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

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