Clinical significance of subclinical atherosclerosis in retinal vein occlusion
Abstract Retinal vein occlusion (RVO) is associated with atherosclerotic cardiovascular risk factors; however, its association with the specific markers of subclinical atherosclerosis has not yet been established. To investigate this association, we compared 70 patients with RVO to 70 age- and sex-m...
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Nature Portfolio
2021
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oai:doaj.org-article:a12f53be04624362bb6e0178f93dcebd2021-12-02T17:52:41ZClinical significance of subclinical atherosclerosis in retinal vein occlusion10.1038/s41598-021-91401-12045-2322https://doaj.org/article/a12f53be04624362bb6e0178f93dcebd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91401-1https://doaj.org/toc/2045-2322Abstract Retinal vein occlusion (RVO) is associated with atherosclerotic cardiovascular risk factors; however, its association with the specific markers of subclinical atherosclerosis has not yet been established. To investigate this association, we compared 70 patients with RVO to 70 age- and sex-matched patients without RVO. Low-density lipoprotein cholesterol (LDL-C) levels and brachial-ankle pulse wave velocity (baPWV) were significantly higher in the RVO group than in the control group. Carotid plaques (54.3% vs. 28.6%, p = 0.004) were more frequent in the RVO group. Multivariate logistic regression analysis showed that the presence of carotid plaques (odds ratio [OR]: 3.15, 95% confidence interval [CI] 1.38–7.16, p = 0.006), as well as smoking, LDL-C level, and baPWV were associated with RVO. Additionally, a multinomial logistic regression model showed that the presence of carotid plaques (OR: 3.94, 95% CI 1.65–9.41, p = 0.002) and LDL-C level were associated with branch RVO, whereas smoking and baPWV were associated with central RVO. In conclusion, RVO was associated with subclinical atherosclerosis markers, including carotid plaques and baPWV. These results support the hypothesis that atherosclerosis contributes to the etiology of RVO and suggest the evaluation of subclinical atherosclerosis in patients with RVO.Minhyung LyuYonggu LeeByung Sik KimHyun-Jin KimRimkyung HongYong Un ShinHeeyoon ChoJeong-Hun ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Minhyung Lyu Yonggu Lee Byung Sik Kim Hyun-Jin Kim Rimkyung Hong Yong Un Shin Heeyoon Cho Jeong-Hun Shin Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| description |
Abstract Retinal vein occlusion (RVO) is associated with atherosclerotic cardiovascular risk factors; however, its association with the specific markers of subclinical atherosclerosis has not yet been established. To investigate this association, we compared 70 patients with RVO to 70 age- and sex-matched patients without RVO. Low-density lipoprotein cholesterol (LDL-C) levels and brachial-ankle pulse wave velocity (baPWV) were significantly higher in the RVO group than in the control group. Carotid plaques (54.3% vs. 28.6%, p = 0.004) were more frequent in the RVO group. Multivariate logistic regression analysis showed that the presence of carotid plaques (odds ratio [OR]: 3.15, 95% confidence interval [CI] 1.38–7.16, p = 0.006), as well as smoking, LDL-C level, and baPWV were associated with RVO. Additionally, a multinomial logistic regression model showed that the presence of carotid plaques (OR: 3.94, 95% CI 1.65–9.41, p = 0.002) and LDL-C level were associated with branch RVO, whereas smoking and baPWV were associated with central RVO. In conclusion, RVO was associated with subclinical atherosclerosis markers, including carotid plaques and baPWV. These results support the hypothesis that atherosclerosis contributes to the etiology of RVO and suggest the evaluation of subclinical atherosclerosis in patients with RVO. |
| format |
article |
| author |
Minhyung Lyu Yonggu Lee Byung Sik Kim Hyun-Jin Kim Rimkyung Hong Yong Un Shin Heeyoon Cho Jeong-Hun Shin |
| author_facet |
Minhyung Lyu Yonggu Lee Byung Sik Kim Hyun-Jin Kim Rimkyung Hong Yong Un Shin Heeyoon Cho Jeong-Hun Shin |
| author_sort |
Minhyung Lyu |
| title |
Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| title_short |
Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| title_full |
Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| title_fullStr |
Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| title_full_unstemmed |
Clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| title_sort |
clinical significance of subclinical atherosclerosis in retinal vein occlusion |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a12f53be04624362bb6e0178f93dcebd |
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