Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.

Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the...

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Autores principales:	Ana Viñuela, L Basten Snoek, Joost A G Riksen, Jan E Kammenga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a13158eaa03f4001bf20287382b02414
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spelling	oai:doaj.org-article:a13158eaa03f4001bf20287382b024142021-11-04T06:08:53ZGene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.1932-620310.1371/journal.pone.0024676https://doaj.org/article/a13158eaa03f4001bf20287382b024142011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931806/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides.Ana ViñuelaL Basten SnoekJoost A G RiksenJan E KammengaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24676 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
description	Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides.
format	article
author	Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga
author_facet	Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga
author_sort	Ana Viñuela
title	Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
title_short	Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
title_full	Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
title_fullStr	Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
title_full_unstemmed	Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
title_sort	gene expression modifications by temperature-toxicants interactions in caenorhabditis elegans.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a13158eaa03f4001bf20287382b02414
work_keys_str_mv	AT anavinuela geneexpressionmodificationsbytemperaturetoxicantsinteractionsincaenorhabditiselegans AT lbastensnoek geneexpressionmodificationsbytemperaturetoxicantsinteractionsincaenorhabditiselegans AT joostagriksen geneexpressionmodificationsbytemperaturetoxicantsinteractionsincaenorhabditiselegans AT janekammenga geneexpressionmodificationsbytemperaturetoxicantsinteractionsincaenorhabditiselegans
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Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.

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