Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study

Body composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis...

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Autores principales:	Lara Pozzuto, Marina Nogueira Silveira, Maria Carolina Santos Mendes, Lígia Traldi Macedo, Felipe Osório Costa, Carlos Augusto Real Martinez, Cláudio Saddy Rodrigues Coy, Ademar Dantas da Cunha Júnior, José Barreto Campello Carvalheira
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	skeletal muscle radiodensity cancer survival computerized tomography sarcopenia skeletal muscle mass Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a13324fbc0d84e45b21da93548d978df
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spelling	oai:doaj.org-article:a13324fbc0d84e45b21da93548d978df2021-11-11T08:10:41ZMyosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study2234-943X10.3389/fonc.2021.762444https://doaj.org/article/a13324fbc0d84e45b21da93548d978df2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.762444/fullhttps://doaj.org/toc/2234-943XBody composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis with prognosis in colon cancer (CC) and rectal cancer (RC) is still unclear. CT was performed at the L3 level to assess body composition features in 227 patients with CRC. Clinical parameters were collected. Overall survival (OS) was the primary outcome, and the secondary outcome was disease-free survival (DFS). Skeletal muscle attenuation and intramuscular adipose tissue area were associated with DFS (p = 0.003 and p = 0.011, respectively) and OS (p < 0.001 and p < 0.001, respectively) in CC patients but not in RC patients. Only the skeletal muscle area was associated with better prognosis related to OS in RC patients (p = 0.009). When CC and RC were analyzed separately, myosteatosis influenced survival negatively in CC patients, worsening DFS survival (hazard ratio [HR], 2.70; 95% confidence interval [CI], 1.07–6.82; p = 0.035) and OS (HR, 5.76; 95% CI, 1.31–25.40; p = 0.021). By contrast, the presence of myosteatosis did not influence DFS (HR, 1.02; 95% CI, 0.52–2.03; p = 0.944) or OS (HR, 0.76; 95% CI, 0.33–1.77; p = 0.529) in RC patients. Our study revealed the interference of myosteatosis in the therapy and survival of patients with CC but not in those with RC, strengthening the value of grouping the two types of cancer in body composition analyses.Lara PozzutoMarina Nogueira SilveiraMaria Carolina Santos MendesLígia Traldi MacedoFelipe Osório CostaCarlos Augusto Real MartinezCláudio Saddy Rodrigues CoyAdemar Dantas da Cunha JúniorAdemar Dantas da Cunha JúniorJosé Barreto Campello CarvalheiraFrontiers Media S.A.articleskeletal muscle radiodensitycancersurvivalcomputerized tomographysarcopeniaskeletal muscle massNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle radiodensity cancer survival computerized tomography sarcopenia skeletal muscle mass Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	skeletal muscle radiodensity cancer survival computerized tomography sarcopenia skeletal muscle mass Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
description	Body composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis with prognosis in colon cancer (CC) and rectal cancer (RC) is still unclear. CT was performed at the L3 level to assess body composition features in 227 patients with CRC. Clinical parameters were collected. Overall survival (OS) was the primary outcome, and the secondary outcome was disease-free survival (DFS). Skeletal muscle attenuation and intramuscular adipose tissue area were associated with DFS (p = 0.003 and p = 0.011, respectively) and OS (p < 0.001 and p < 0.001, respectively) in CC patients but not in RC patients. Only the skeletal muscle area was associated with better prognosis related to OS in RC patients (p = 0.009). When CC and RC were analyzed separately, myosteatosis influenced survival negatively in CC patients, worsening DFS survival (hazard ratio [HR], 2.70; 95% confidence interval [CI], 1.07–6.82; p = 0.035) and OS (HR, 5.76; 95% CI, 1.31–25.40; p = 0.021). By contrast, the presence of myosteatosis did not influence DFS (HR, 1.02; 95% CI, 0.52–2.03; p = 0.944) or OS (HR, 0.76; 95% CI, 0.33–1.77; p = 0.529) in RC patients. Our study revealed the interference of myosteatosis in the therapy and survival of patients with CC but not in those with RC, strengthening the value of grouping the two types of cancer in body composition analyses.
format	article
author	Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira
author_facet	Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira
author_sort	Lara Pozzuto
title	Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
title_short	Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
title_full	Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
title_fullStr	Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
title_full_unstemmed	Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
title_sort	myosteatosis differentially affects the prognosis of non-metastatic colon and rectal cancer patients: an exploratory study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a13324fbc0d84e45b21da93548d978df
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Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study

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