Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

Omecamtiv mecarbil is a small molecule effector under clinical trial for the treatment of systolic heart failure. Here the authors define the molecular mechanisms of its inotropic action and find it can increase the efficiency of contraction in muscle fibres when the orthophosphate concentration ris...

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Autores principales:	Serena Governali, Marco Caremani, Cristina Gallart, Irene Pertici, Ger Stienen, Gabriella Piazzesi, Coen Ottenheijm, Vincenzo Lombardi, Marco Linari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1356051549946cab751e8490d8aee60
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spelling	oai:doaj.org-article:a1356051549946cab751e8490d8aee602021-12-02T15:23:10ZOrthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil10.1038/s41467-020-17143-22041-1723https://doaj.org/article/a1356051549946cab751e8490d8aee602020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17143-2https://doaj.org/toc/2041-1723Omecamtiv mecarbil is a small molecule effector under clinical trial for the treatment of systolic heart failure. Here the authors define the molecular mechanisms of its inotropic action and find it can increase the efficiency of contraction in muscle fibres when the orthophosphate concentration rises with the beat frequency.Serena GovernaliMarco CaremaniCristina GallartIrene PerticiGer StienenGabriella PiazzesiCoen OttenheijmVincenzo LombardiMarco LinariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Serena Governali Marco Caremani Cristina Gallart Irene Pertici Ger Stienen Gabriella Piazzesi Coen Ottenheijm Vincenzo Lombardi Marco Linari Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
description	Omecamtiv mecarbil is a small molecule effector under clinical trial for the treatment of systolic heart failure. Here the authors define the molecular mechanisms of its inotropic action and find it can increase the efficiency of contraction in muscle fibres when the orthophosphate concentration rises with the beat frequency.
format	article
author	Serena Governali Marco Caremani Cristina Gallart Irene Pertici Ger Stienen Gabriella Piazzesi Coen Ottenheijm Vincenzo Lombardi Marco Linari
author_facet	Serena Governali Marco Caremani Cristina Gallart Irene Pertici Ger Stienen Gabriella Piazzesi Coen Ottenheijm Vincenzo Lombardi Marco Linari
author_sort	Serena Governali
title	Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
title_short	Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
title_full	Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
title_fullStr	Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
title_full_unstemmed	Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
title_sort	orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a1356051549946cab751e8490d8aee60
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Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

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