X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study

Abstract Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In...

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Autores principales:	Josef Scholz, Nathalie Roiser, Eva-Maria Braig, Christian Petrich, Lorenz Birnbacher, Jana Andrejewski, Melanie A. Kimm, Andreas Sauter, Madleen Busse, Rüdiger Korbel, Julia Herzen, Daniela Pfeiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1360e89fc2749debb4f09e6f10e2400
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spelling	oai:doaj.org-article:a1360e89fc2749debb4f09e6f10e24002021-12-02T15:15:04ZX-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study10.1038/s41598-021-98151-02045-2322https://doaj.org/article/a1360e89fc2749debb4f09e6f10e24002021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98151-0https://doaj.org/toc/2045-2322Abstract Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In fact, most patients are diagnosed or even misdiagnosed based on manifested clinical signs, as indicated by the unchanged premature mortality among gout patients over the past decade, although effective treatment is now available. An alternative, non-invasive approach for the detection of MSU crystals is X-ray dark-field radiography. In our work, we demonstrate that dark-field X-ray radiography can detect naturally developed gout in animals with high diagnostic sensitivity and specificity based on the in situ measurement of MSU crystals. With the results of this study as a potential basis for further research, we believe that X-ray dark-field radiography has the potential to substantially improve gout diagnostics.Josef ScholzNathalie RoiserEva-Maria BraigChristian PetrichLorenz BirnbacherJana AndrejewskiMelanie A. KimmAndreas SauterMadleen BusseRüdiger KorbelJulia HerzenDaniela PfeifferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Josef Scholz Nathalie Roiser Eva-Maria Braig Christian Petrich Lorenz Birnbacher Jana Andrejewski Melanie A. Kimm Andreas Sauter Madleen Busse Rüdiger Korbel Julia Herzen Daniela Pfeiffer X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
description	Abstract Gout is the most common form of inflammatory arthritis, caused by the deposition of monosodium urate (MSU) crystals in peripheral joints and tissue. Detection of MSU crystals is essential for definitive diagnosis, however the gold standard is an invasive process which is rarely utilized. In fact, most patients are diagnosed or even misdiagnosed based on manifested clinical signs, as indicated by the unchanged premature mortality among gout patients over the past decade, although effective treatment is now available. An alternative, non-invasive approach for the detection of MSU crystals is X-ray dark-field radiography. In our work, we demonstrate that dark-field X-ray radiography can detect naturally developed gout in animals with high diagnostic sensitivity and specificity based on the in situ measurement of MSU crystals. With the results of this study as a potential basis for further research, we believe that X-ray dark-field radiography has the potential to substantially improve gout diagnostics.
format	article
author	Josef Scholz Nathalie Roiser Eva-Maria Braig Christian Petrich Lorenz Birnbacher Jana Andrejewski Melanie A. Kimm Andreas Sauter Madleen Busse Rüdiger Korbel Julia Herzen Daniela Pfeiffer
author_facet	Josef Scholz Nathalie Roiser Eva-Maria Braig Christian Petrich Lorenz Birnbacher Jana Andrejewski Melanie A. Kimm Andreas Sauter Madleen Busse Rüdiger Korbel Julia Herzen Daniela Pfeiffer
author_sort	Josef Scholz
title	X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
title_short	X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
title_full	X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
title_fullStr	X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
title_full_unstemmed	X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
title_sort	x-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1360e89fc2749debb4f09e6f10e2400
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X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study

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