Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.

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Autores principales:	Alyssa La Belle Flynn, Benjamin C. Calhoun, Arishya Sharma, Jenny C. Chang, Alexandru Almasan, William P. Schiemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a138f0bd72854b59891da7dffc77c399
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spelling	oai:doaj.org-article:a138f0bd72854b59891da7dffc77c3992021-12-02T17:02:11ZAutophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression10.1038/s41467-019-11640-92041-1723https://doaj.org/article/a138f0bd72854b59891da7dffc77c3992019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11640-9https://doaj.org/toc/2041-1723Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.Alyssa La Belle FlynnBenjamin C. CalhounArishya SharmaJenny C. ChangAlexandru AlmasanWilliam P. SchiemannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
description	Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.
format	article
author	Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann
author_facet	Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann
author_sort	Alyssa La Belle Flynn
title	Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
title_short	Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
title_full	Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
title_fullStr	Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
title_full_unstemmed	Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
title_sort	autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing pfkfb3 expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a138f0bd72854b59891da7dffc77c399
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Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

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