Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis
Abstract The differentiation of non-small cell lung cancer (NSCLC) and radiation pneumonitis (RP) is critically essential for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with NSCLC. The aim of this study was to assess the ability of 18F...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a13deed6066f4c098068515e1d25d262 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a13deed6066f4c098068515e1d25d262 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a13deed6066f4c098068515e1d25d2622021-12-02T15:02:48ZDifferentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis10.1038/s41598-021-90674-w2045-2322https://doaj.org/article/a13deed6066f4c098068515e1d25d2622021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90674-whttps://doaj.org/toc/2045-2322Abstract The differentiation of non-small cell lung cancer (NSCLC) and radiation pneumonitis (RP) is critically essential for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with NSCLC. The aim of this study was to assess the ability of 18F-FDG PET/CT metabolic parameters and its textural image features to differentiate NSCLC from RP after CIRT to develop a differential diagnosis of malignancy and benign lesion. We retrospectively analyzed 18F-FDG PET/CT image data from 32 patients with histopathologically proven NSCLC who were scheduled to undergo CIRT and 31 patients diagnosed with RP after CIRT. The SUV parameters, metabolic tumor volume (MTV), total lesion glycolysis (TLG) as well as fifty-six texture parameters derived from seven matrices were determined using PETSTAT image-analysis software. Data were statistically compared between NSCLC and RP using Wilcoxon rank-sum tests. Diagnostic accuracy was assessed using receiver operating characteristics (ROC) curves. Several texture parameters significantly differed between NSCLC and RP (p < 0.05). The parameters that were high in areas under the ROC curves (AUC) were as follows: SUVmax, 0.64; GLRLM run percentage, 0.83 and NGTDM coarseness, 0.82. Diagnostic accuracy was improved using GLRLM run percentage or NGTDM coarseness compared with SUVmax (p < 0.01). The texture parameters of 18F-FDG uptake yielded excellent outcomes for differentiating NSCLC from radiation pneumonitis after CIRT, which outperformed SUV-based evaluation. In particular, GLRLM run percentage and NGTDM coarseness of 18F-FDG PET/CT images would be appropriate parameters that can offer high diagnostic accuracy.Makito SugaRyuichi NishiiKenta MiwaYuto KamitakaKana YamazakiKentaro TamuraNaoyoshi YamamotoRyosuke KohnoMasato KobayashiKatsuyuki TanimotoHiroshi TsujiTatsuya HigashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Makito Suga Ryuichi Nishii Kenta Miwa Yuto Kamitaka Kana Yamazaki Kentaro Tamura Naoyoshi Yamamoto Ryosuke Kohno Masato Kobayashi Katsuyuki Tanimoto Hiroshi Tsuji Tatsuya Higashi Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| description |
Abstract The differentiation of non-small cell lung cancer (NSCLC) and radiation pneumonitis (RP) is critically essential for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with NSCLC. The aim of this study was to assess the ability of 18F-FDG PET/CT metabolic parameters and its textural image features to differentiate NSCLC from RP after CIRT to develop a differential diagnosis of malignancy and benign lesion. We retrospectively analyzed 18F-FDG PET/CT image data from 32 patients with histopathologically proven NSCLC who were scheduled to undergo CIRT and 31 patients diagnosed with RP after CIRT. The SUV parameters, metabolic tumor volume (MTV), total lesion glycolysis (TLG) as well as fifty-six texture parameters derived from seven matrices were determined using PETSTAT image-analysis software. Data were statistically compared between NSCLC and RP using Wilcoxon rank-sum tests. Diagnostic accuracy was assessed using receiver operating characteristics (ROC) curves. Several texture parameters significantly differed between NSCLC and RP (p < 0.05). The parameters that were high in areas under the ROC curves (AUC) were as follows: SUVmax, 0.64; GLRLM run percentage, 0.83 and NGTDM coarseness, 0.82. Diagnostic accuracy was improved using GLRLM run percentage or NGTDM coarseness compared with SUVmax (p < 0.01). The texture parameters of 18F-FDG uptake yielded excellent outcomes for differentiating NSCLC from radiation pneumonitis after CIRT, which outperformed SUV-based evaluation. In particular, GLRLM run percentage and NGTDM coarseness of 18F-FDG PET/CT images would be appropriate parameters that can offer high diagnostic accuracy. |
| format |
article |
| author |
Makito Suga Ryuichi Nishii Kenta Miwa Yuto Kamitaka Kana Yamazaki Kentaro Tamura Naoyoshi Yamamoto Ryosuke Kohno Masato Kobayashi Katsuyuki Tanimoto Hiroshi Tsuji Tatsuya Higashi |
| author_facet |
Makito Suga Ryuichi Nishii Kenta Miwa Yuto Kamitaka Kana Yamazaki Kentaro Tamura Naoyoshi Yamamoto Ryosuke Kohno Masato Kobayashi Katsuyuki Tanimoto Hiroshi Tsuji Tatsuya Higashi |
| author_sort |
Makito Suga |
| title |
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| title_short |
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| title_full |
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| title_fullStr |
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| title_full_unstemmed |
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis |
| title_sort |
differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18f-fdg pet/ct texture analysis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a13deed6066f4c098068515e1d25d262 |
| work_keys_str_mv |
AT makitosuga differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT ryuichinishii differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT kentamiwa differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT yutokamitaka differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT kanayamazaki differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT kentarotamura differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT naoyoshiyamamoto differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT ryosukekohno differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT masatokobayashi differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT katsuyukitanimoto differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT hiroshitsuji differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis AT tatsuyahigashi differentiationbetweennonsmallcelllungcancerandradiationpneumonitisaftercarbonionradiotherapyby18ffdgpetcttextureanalysis |
| _version_ |
1718389093986992128 |