Clinical and allergological analysis of ocular manifestations of sick building syndrome

Yusuke Saeki,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: The disease concept of sick building syndrome (SBS) is still unclear. Ocul...

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Autores principales:	Saeki Y, Kadonosono K, Uchio E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	sick building syndrome allergic conjunctival disease cytokine vernal keratoconjunctivitis IgE Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a13f1aaddbdc4188acf9730d587bb1b4
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spelling	oai:doaj.org-article:a13f1aaddbdc4188acf9730d587bb1b42021-12-02T03:43:15ZClinical and allergological analysis of ocular manifestations of sick building syndrome1177-5483https://doaj.org/article/a13f1aaddbdc4188acf9730d587bb1b42017-03-01T00:00:00Zhttps://www.dovepress.com/clinical-and-allergological-analysis-of-ocular-manifestations-of-sick--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yusuke Saeki,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: The disease concept of sick building syndrome (SBS) is still unclear. Ocular mucous membrane irritation is one of the major symptoms of SBS. However, the immunological aspects of the ocular complications of SBS are not yet clarified. The clinical and allergological aspects of SBS cases with ocular disorders with special reference to allergic conjunctival diseases (ACD) were analyzed, especially with respect to local immunological features. Methods: Twelve cases of SBS with ocular findings and 49 cases of ACD (allergic conjunctivitis [AC], atopic keratoconjunctivitis [AKC], and vernal keratoconjunctivitis [VKC]) for comparison were evaluated. The clinical findings in SBS and ACD were scored, and tear film breakup time (BUT) was measured. Cytokine (interferon-γ [IFN-γ], interleukin [IL]-2, IL-4, IL-5, IL-6, IL-8, and IL-13) concentrations in tears were analyzed by cytometric bead arrays. Eosinophil count in peripheral blood, total IgE in serum, and multiple allergen simultaneous test (MAST) for antigen-specific IgE were also measured. Results: In SBS, conjunctival lesions were observed in all cases, and corneal abnormalities were found in two-thirds of the cases. Limbal lesions were observed in 2 pediatric cases. Mean serum total IgE level in SBS was significantly higher than that in AC; however, it was significantly lower than that in AKC and VKC. Eosinophil count in peripheral blood and number of positive allergens in MAST were significantly lower in SBS than in AKC and VKC. Significant elevation of tear IL-4 was observed in SBS and ACD. However, in contrast to ACD, elevation of other cytokines in tears was not observed in SBS. Mean tear BUT in SBS was in the normal range. Conclusion: From these results, SBS is thought to be partially induced by an allergic response. However, clinical dissociation of the ocular clinical findings and local immunological features in tear cytokines may suggest that SBS belongs to a different entity from ACD. Keywords: sick building syndrome, allergic conjunctival disease, cytokine, vernal keratoconjunctivitis, IgESaeki YKadonosono KUchio EDove Medical Pressarticlesick building syndromeallergic conjunctival diseasecytokinevernal keratoconjunctivitisIgEOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 517-522 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	sick building syndrome allergic conjunctival disease cytokine vernal keratoconjunctivitis IgE Ophthalmology RE1-994
spellingShingle	sick building syndrome allergic conjunctival disease cytokine vernal keratoconjunctivitis IgE Ophthalmology RE1-994 Saeki Y Kadonosono K Uchio E Clinical and allergological analysis of ocular manifestations of sick building syndrome
description	Yusuke Saeki,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: The disease concept of sick building syndrome (SBS) is still unclear. Ocular mucous membrane irritation is one of the major symptoms of SBS. However, the immunological aspects of the ocular complications of SBS are not yet clarified. The clinical and allergological aspects of SBS cases with ocular disorders with special reference to allergic conjunctival diseases (ACD) were analyzed, especially with respect to local immunological features. Methods: Twelve cases of SBS with ocular findings and 49 cases of ACD (allergic conjunctivitis [AC], atopic keratoconjunctivitis [AKC], and vernal keratoconjunctivitis [VKC]) for comparison were evaluated. The clinical findings in SBS and ACD were scored, and tear film breakup time (BUT) was measured. Cytokine (interferon-γ [IFN-γ], interleukin [IL]-2, IL-4, IL-5, IL-6, IL-8, and IL-13) concentrations in tears were analyzed by cytometric bead arrays. Eosinophil count in peripheral blood, total IgE in serum, and multiple allergen simultaneous test (MAST) for antigen-specific IgE were also measured. Results: In SBS, conjunctival lesions were observed in all cases, and corneal abnormalities were found in two-thirds of the cases. Limbal lesions were observed in 2 pediatric cases. Mean serum total IgE level in SBS was significantly higher than that in AC; however, it was significantly lower than that in AKC and VKC. Eosinophil count in peripheral blood and number of positive allergens in MAST were significantly lower in SBS than in AKC and VKC. Significant elevation of tear IL-4 was observed in SBS and ACD. However, in contrast to ACD, elevation of other cytokines in tears was not observed in SBS. Mean tear BUT in SBS was in the normal range. Conclusion: From these results, SBS is thought to be partially induced by an allergic response. However, clinical dissociation of the ocular clinical findings and local immunological features in tear cytokines may suggest that SBS belongs to a different entity from ACD. Keywords: sick building syndrome, allergic conjunctival disease, cytokine, vernal keratoconjunctivitis, IgE
format	article
author	Saeki Y Kadonosono K Uchio E
author_facet	Saeki Y Kadonosono K Uchio E
author_sort	Saeki Y
title	Clinical and allergological analysis of ocular manifestations of sick building syndrome
title_short	Clinical and allergological analysis of ocular manifestations of sick building syndrome
title_full	Clinical and allergological analysis of ocular manifestations of sick building syndrome
title_fullStr	Clinical and allergological analysis of ocular manifestations of sick building syndrome
title_full_unstemmed	Clinical and allergological analysis of ocular manifestations of sick building syndrome
title_sort	clinical and allergological analysis of ocular manifestations of sick building syndrome
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a13f1aaddbdc4188acf9730d587bb1b4
work_keys_str_mv	AT saekiy clinicalandallergologicalanalysisofocularmanifestationsofsickbuildingsyndrome AT kadonosonok clinicalandallergologicalanalysisofocularmanifestationsofsickbuildingsyndrome AT uchioe clinicalandallergologicalanalysisofocularmanifestationsofsickbuildingsyndrome
_version_	1718401686924427264

Clinical and allergological analysis of ocular manifestations of sick building syndrome

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