Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial

Abstract Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodywei...

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Autores principales:	Hayeon Kim, Gyulee Park, Joon-Ho Shin, Joshua H. You
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a142a7b0432442b8a41b6bb6f4d3d9f8
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spelling	oai:doaj.org-article:a142a7b0432442b8a41b6bb6f4d3d9f82021-12-02T16:06:40ZNeuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial10.1038/s41598-020-69367-32045-2322https://doaj.org/article/a142a7b0432442b8a41b6bb6f4d3d9f82020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69367-3https://doaj.org/toc/2045-2322Abstract Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodyweight-supported treadmill training (BWST) on cortical activation in individuals with hemiparetic stroke. Twenty-three men and five women aged 53.2 ± 11.2 years were recruited and randomly assigned to participate in E-RAGT (n = 14) or BWST (n = 14) for 30 min/day, 5 days/week, for 4 weeks. Cortical activity, lower limb motor function, and gait speed were evaluated before and after training. Activation of the primary sensorimotor cortex, supplementary motor area, and premotor cortex in the affected hemisphere significantly increased only in the E-RAGT group, although there were no significant between-group differences. Clinical outcomes, including the Fugl-Meyer assessment (FMA), timed up and go test, and 10-m walk test scores, improved after training in both groups, with significantly better FMA scores in the E-RAGT group than in the BWST group. These findings suggest that E-RAGT effectively improves neuroplastic outcomes in hemiparetic stroke, although its superiority over conventional training remains unclear. This may have clinical implications and provides insight for clinicians interested in locomotor neurorehabilitation after hemiparetic stroke. Trial Registration: ClinicalTrials.gov Identifier NCT04054739 (12/08/2019).Hayeon KimGyulee ParkJoon-Ho ShinJoshua H. YouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hayeon Kim Gyulee Park Joon-Ho Shin Joshua H. You Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
description	Abstract Detecting neuroplastic changes during locomotor neurorehabilitation is crucial for independent primal motor behaviours. However, long-term locomotor training-related neuroplasticity remains unexplored. We compared the effects of end-effector robot-assisted gait training (E-RAGT) and bodyweight-supported treadmill training (BWST) on cortical activation in individuals with hemiparetic stroke. Twenty-three men and five women aged 53.2 ± 11.2 years were recruited and randomly assigned to participate in E-RAGT (n = 14) or BWST (n = 14) for 30 min/day, 5 days/week, for 4 weeks. Cortical activity, lower limb motor function, and gait speed were evaluated before and after training. Activation of the primary sensorimotor cortex, supplementary motor area, and premotor cortex in the affected hemisphere significantly increased only in the E-RAGT group, although there were no significant between-group differences. Clinical outcomes, including the Fugl-Meyer assessment (FMA), timed up and go test, and 10-m walk test scores, improved after training in both groups, with significantly better FMA scores in the E-RAGT group than in the BWST group. These findings suggest that E-RAGT effectively improves neuroplastic outcomes in hemiparetic stroke, although its superiority over conventional training remains unclear. This may have clinical implications and provides insight for clinicians interested in locomotor neurorehabilitation after hemiparetic stroke. Trial Registration: ClinicalTrials.gov Identifier NCT04054739 (12/08/2019).
format	article
author	Hayeon Kim Gyulee Park Joon-Ho Shin Joshua H. You
author_facet	Hayeon Kim Gyulee Park Joon-Ho Shin Joshua H. You
author_sort	Hayeon Kim
title	Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
title_short	Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
title_full	Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
title_fullStr	Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
title_full_unstemmed	Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
title_sort	neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a142a7b0432442b8a41b6bb6f4d3d9f8
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Neuroplastic effects of end-effector robotic gait training for hemiparetic stroke: a randomised controlled trial

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